INT131850

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Context Info
Confidence 0.72
First Reported 2000
Last Reported 2006
Negated 3
Speculated 0
Reported most in Body
Documents 17
Total Number 35
Disease Relevance 29.06
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RHOC) signal transduction (RHOC) plasma membrane (RHOC)
nucleus (RHOC) intracellular (RHOC) GTPase activity (RHOC)
Anatomy Link Frequency
HPAF-II 7
pancreas 2
BxPC-3 2
PC-3 2
RHOC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 380 100.00 Very High Very High Very High
Chronic pancreatitis 38 97.88 Very High Very High Very High
Spinal cord 4 90.20 High High
Intractable pain 4 87.96 High High
cytokine 36 25.32 Quite Low
fibrosis 19 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
COX2 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Breast Neoplasms 1526 100.00 Very High Very High Very High
Cancer 1091 99.98 Very High Very High Very High
Adenocarcinoma 975 99.84 Very High Very High Very High
INFLAMMATION 228 99.84 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 156 99.72 Very High Very High Very High
Adhesions 16 99.60 Very High Very High Very High
Stress 12 99.10 Very High Very High Very High
Malignant Neoplastic Disease 30 98.92 Very High Very High Very High
Breast Cancer 301 98.64 Very High Very High Very High
Pancreatic Cancer 133 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, we demonstrate that RhoC GTPase is expressed and active in PC-3 CaP cells.
Gene_expression (expressed) of RhoC in PC-3
1) Confidence 0.72 Published 2006 Journal Oncogene Section Abstract Doc Link 16314838 Disease Relevance 1.11 Pain Relevance 0.12
RhoC inhibition, either pharmacologically with C3 exotransferase or molecularly through expression of a dominant-negative RhoC, promotes IGF-I stimulated random motility but decreases in vitro invasion and experimental metastases.
Gene_expression (expression) of RhoC associated with metastasis
2) Confidence 0.72 Published 2006 Journal Oncogene Section Abstract Doc Link 16314838 Disease Relevance 1.08 Pain Relevance 0.11
Increased expression of RhoC GTPase is linked to enhanced metastatic potential in multiple cancers; however, the role of RhoC GTPase in CaP metastasis has not been addressed.
Gene_expression (expression) of RhoC associated with cancer and metastasis
3) Confidence 0.72 Published 2006 Journal Oncogene Section Abstract Doc Link 16314838 Disease Relevance 1.16 Pain Relevance 0.13
These data suggest that RhoC inhibition leads to activation of other GTPases involved in nondirected motility and that expression of active RhoC is required for the invasive phenotype of PC-3 cells.
Gene_expression (expression) of RhoC in PC-3
4) Confidence 0.72 Published 2006 Journal Oncogene Section Abstract Doc Link 16314838 Disease Relevance 0.81 Pain Relevance 0.09
Finally, IBC and non-IBC showed similar expression levels of the genes WISP3/LIBC, RhoC and E-cadherin, a finding that conflicts with several other reports [31].
Gene_expression (expression) of RhoC associated with inflammatory breast neoplasms
5) Confidence 0.66 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.09 Pain Relevance 0.07
RhoC GTPase expression seems to be modulated by WISP3, and these two genes might thus act in concert to give rise to IBC [44].
Gene_expression (expression) of RhoC associated with inflammatory breast neoplasms
6) Confidence 0.66 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.45 Pain Relevance 0.21
LIBC was underexpressed in 80% of IBC samples versus 21% in non-inflammatory LABC samples, and RhoC was overexpressed in 90% and 36%, respectively [35].
Gene_expression (overexpressed) of RhoC associated with inflammatory breast neoplasms, inflammation and advanced or metastatic breast cancer
7) Confidence 0.66 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.59 Pain Relevance 0.22
Using quantitative RT-PCR, however, we found RhoC overexpression only in three of 32 inflammatory breast tumor samples [17].
Gene_expression (overexpression) of RhoC associated with inflammation and breast cancer
8) Confidence 0.66 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.43 Pain Relevance 0.21
Next, to directly implicate RhoC in PC cell migration and invasion, we generated stable HPAF-II dominant negative RhoC (dnRhoC) transfectants.
Gene_expression (transfectants) of RhoC in HPAF-II associated with adenocarcinoma
9) Confidence 0.64 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.22 Pain Relevance 0
Figure 2B is a comparison of RhoC expression and activation in the BxPC-3 and HPAF-II cell lines.
Gene_expression (expression) of RhoC in HPAF-II
10) Confidence 0.64 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.42 Pain Relevance 0
RT-PCR and immunoblot analysis confirm that RhoC is highly expressed on the mRNA and protein levels both in the BxPC-3 and HPAF-II cells.
Gene_expression (expressed) of RhoC in BxPC-3
11) Confidence 0.64 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.40 Pain Relevance 0
RhoC was overexpressed and found in primary tumors that were locally invasive and in tumors from a variety of metastatic sites [30].
Gene_expression (overexpressed) of RhoC associated with cancer
12) Confidence 0.64 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.67 Pain Relevance 0.15
In PC tumors, RhoC was overexpressed 3- to 6-fold compared to normal and 2- to 4-fold compared with chronic pancreatitis (Craig Logsdon, personal communication) [31].
Gene_expression (overexpressed) of RhoC associated with adenocarcinoma, cancer and chronic pancreatitis
13) Confidence 0.64 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.57 Pain Relevance 0.20
RT-PCR of RhoC expression in PC cell lines was performed as previously described [54] using primers specific for RhoC GTPase and GAPDH control.
Gene_expression (expression) of RhoC associated with adenocarcinoma
14) Confidence 0.64 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.17 Pain Relevance 0
These data, combined with the observation that over-expression of RhoC GTPase correlates with tumor progression in aggressive ductal adenocarcinoma of the pancreas [40], suggest that RhoC is a key element in the IBC metastatic phenotype.
Gene_expression (over) of RhoC in pancreas associated with inflammatory breast neoplasms, adenocarcinoma and cancer
15) Confidence 0.61 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 0.80 Pain Relevance 0
In addition to increased stress fiber and focal adhesion contact formation, over-expression of RhoC could activate other Rho family members (ie RhoA, rac and/or cdc42) through signaling feedback loops [39], leading to dynamic cytoskeletal reorganization and a motile/metastatic cell.
Gene_expression (over) of RhoC associated with stress and adhesions
16) Confidence 0.61 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.17 Pain Relevance 0.03
Transfection and over-expression of RhoC GTPase in Epstein-Barr virus-immortalized HME cells produce highly motile and invasive tumorigenic clones (van Golen et al, unpublished data).
Gene_expression (expression) of RhoC
17) Confidence 0.61 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.04 Pain Relevance 0.03
Only two genes, RhoC GTPase and the lost in inflammatory breast cancer gene LIBC (also known as WISP3), were respectively overexpressed and underexpressed in inflammatory versus stage III non-inflammatory breast tumor samples by in situ hybridization [35].
Gene_expression (overexpressed) of RhoC associated with inflammation and breast cancer
18) Confidence 0.57 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.69 Pain Relevance 0.26
Only two genes, RhoC GTPase and the lost in inflammatory breast cancer gene LIBC (also known as WISP3), were respectively overexpressed and underexpressed in inflammatory versus stage III non-inflammatory breast tumor samples by in situ hybridization [35].
Gene_expression (underexpressed) of RhoC associated with inflammation and breast cancer
19) Confidence 0.57 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.71 Pain Relevance 0.26
As shown, both C3 exotransferase treatment and expression of dnRhoC did not significantly alter total levels of RhoC protein.
Gene_expression (expression) of dnRhoC
20) Confidence 0.56 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.16 Pain Relevance 0

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