INT13186

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Context Info
Confidence 0.68
First Reported 1991
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 113
Total Number 114
Disease Relevance 71.22
Pain Relevance 31.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cells 10
macrophages 2
intestine 2
lymphocytes 2
lung 2
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1938 100.00 Very High Very High Very High
Inflammation 1677 100.00 Very High Very High Very High
chemokine 252 100.00 Very High Very High Very High
rheumatoid arthritis 525 99.62 Very High Very High Very High
fibrosis 134 99.42 Very High Very High Very High
Crohn's disease 35 99.36 Very High Very High Very High
Central nervous system 49 99.12 Very High Very High Very High
Morphine 50 98.96 Very High Very High Very High
antagonist 54 98.52 Very High Very High Very High
fluoxetine 7 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1725 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 304 100.00 Very High Very High Very High
Eosinophilia 52 99.90 Very High Very High Very High
Targeted Disruption 193 99.84 Very High Very High Very High
Inflammatory Bowel Disease 63 99.84 Very High Very High Very High
Stress 358 99.72 Very High Very High Very High
Rheumatoid Arthritis 526 99.62 Very High Very High Very High
Mycobacterial Infection 165 99.60 Very High Very High Very High
Lymphatic System Cancer 14 99.58 Very High Very High Very High
Respiratory Syncytial Virus 172 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protection from EAE progression in IL-4-treated mice was associated with activation of microglia in spinal cord areas where mRNA content of the pro-inflammatory chemokines, macrophage chemoattractant protein-1 (MCP-1) and Rantes, was reduced and that of the anti-inflammatory cytokine IL-4 was increased.
Positive_regulation (increased) of IL-4 in microglia associated with chemokine, multiple sclerosis, inflammation, cytokine and spinal cord
1) Confidence 0.68 Published 2001 Journal Gene Ther. Section Abstract Doc Link 11402297 Disease Relevance 1.73 Pain Relevance 0.78
The stress odor-induced increase in antigen-driven IL-4 and antibody is also blocked by oral administration of naltrexone.
Positive_regulation (increase) of IL-4 associated with stress
2) Confidence 0.67 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10636483 Disease Relevance 0.36 Pain Relevance 0.35
However, in one study the TZDs increased IL4 and IL10, and stimulated GATA3 expression (a transcription factor which shifts cells towards Th2 phenotype) [50]; although in other studies PPAR?
Positive_regulation (increased) of IL4
3) Confidence 0.58 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.44 Pain Relevance 0.36
We had previously shown that chronic morphine treatment in vivo and in vitro decreases IL-2 and IFNgamma (Th1) protein levels and increases IL-4 and IL-5 (Th2) protein levels in a time-dependent manner.
Positive_regulation (increases) of IL-4 associated with morphine
4) Confidence 0.55 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.09 Pain Relevance 0.54
In addition in this paper, we show that chronic morphine treatment resulted in a decrease in IFNgamma and IL-2 mRNA and an increase in IL-4 and IL-5 mRNA accumulation in murine splenocytes.
Positive_regulation (accumulation) of IL-4 associated with morphine
5) Confidence 0.55 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.09 Pain Relevance 0.68
/IL-4 in group B was increased significantly compared with group A.
Positive_regulation (increased) of IL-4
6) Confidence 0.55 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.54 Pain Relevance 0
Morphine treatment increases IL-4 messenger RNA accumulation in PBMCs and increases IL-4 promoter activity in Jurkat T cells.
Positive_regulation (accumulation) of IL-4 in T cells
7) Confidence 0.51 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
RESULTS: Morphine treatment of PBMCs decreases IL-2 and IFN gamma and increases IL-4 and IL-5 as a function of morphine concentration.
Positive_regulation (increases) of IL-4
8) Confidence 0.51 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
Morphine treatment increases IL-4 messenger RNA accumulation in PBMCs and increases IL-4 promoter activity in Jurkat T cells.
Positive_regulation (increases) of IL-4 promoter in T cells
9) Confidence 0.51 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
Although essential for expulsion of N. brasiliensis from the intestine, the precise role of IL-4R?
Positive_regulation (role) of IL-4 in intestine
10) Confidence 0.49 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.81 Pain Relevance 0
Functional analysis confirmed IL-4R?
Positive_regulation (confirmed) of IL-4
11) Confidence 0.49 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.47 Pain Relevance 0
Together, these data are suggestive of smooth muscle IL-4R?
Positive_regulation (smooth muscle) of IL-4 in smooth muscle
12) Confidence 0.49 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.48 Pain Relevance 0.18
On the other hand, the inability of macrophages to become alternatively activated in IL-4R?
Positive_regulation (activated) of IL-4 in macrophages
13) Confidence 0.49 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.28 Pain Relevance 0.24
TH2 cytokine–driven expulsion of N. brasiliensis infections is associated with a concomitant increase in IL-4R?
Positive_regulation (increase) of IL-4 associated with infection and cytokine
14) Confidence 0.45 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.66 Pain Relevance 0.09
The presence of the opioid peptides alpha- and beta-endorphin (-End) but not methionine enkephalin (Met-enk) in in vitro cultures of purified CD4+ T cells, stimulated with concanavalin A in the presence of irradiated spleen cells, resulted in a threefold stimulation of IL-2, IL-4, and IFN-gamma production.
Positive_regulation (stimulation) of IL-4 in spleen associated with enkephalin and opioid
15) Confidence 0.43 Published 1994 Journal Cell. Immunol. Section Abstract Doc Link 7907006 Disease Relevance 0 Pain Relevance 0.44
Conclusion: the clear elevation of IL-4 and IgE could allow to conclude a possible Th2-like dominated allergic response in TDI-exposed BALB/c mouse model.
Positive_regulation (elevation) of IL-4 associated with hypersensitivity
16) Confidence 0.42 Published 2007 Journal Scand. J. Immunol. Section Abstract Doc Link 17257216 Disease Relevance 0.43 Pain Relevance 0.20
Twenty-four hour incubation of mouse splenocytes with MS, removal of the drug and activation with Con-A resulted in a significant (linear regression, P less than 0.001) dose-related inhibition of lymphokine production (IC50 = 0.8 mM) as measured by bioassay for interleukin-2 (IL-2)/interleukin-4 (IL-4).
Positive_regulation (bioassay) of IL-4
17) Confidence 0.40 Published 1991 Journal Immunopharmacology Section Abstract Doc Link 1663496 Disease Relevance 0 Pain Relevance 0.76
Twenty-four hour incubation of mouse splenocytes with MS, removal of the drug and activation with Con-A resulted in a significant (linear regression, P less than 0.001) dose-related inhibition of lymphokine production (IC50 = 0.8 mM) as measured by bioassay for interleukin-2 (IL-2)/interleukin-4 (IL-4).
Positive_regulation (bioassay) of interleukin-4
18) Confidence 0.40 Published 1991 Journal Immunopharmacology Section Abstract Doc Link 1663496 Disease Relevance 0 Pain Relevance 0.71
To assess whether the D. andersoni IL-4 programming activity is mediated via a soluble salivary factors, salivary gland extract (SGE) was administered by intradermal injection.
Spec (whether) Positive_regulation (mediated) of IL-4 in salivary gland
19) Confidence 0.38 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.37 Pain Relevance 0.08
Infestation with pathogen-free D. andersoni nymphs or administration of an intradermal injection of female or male tick salivary gland extract induced significant increases of IL-4 transcripts in skin and draining lymph nodes of BALB/c mice as measured by quantitative real-time RT-PCR.
Positive_regulation (increases) of IL-4 in salivary gland
20) Confidence 0.38 Published 2009 Journal Parasit Vectors Section Abstract Doc Link PMC2764639 Disease Relevance 0.31 Pain Relevance 0.12

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