INT131871

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 5.10
Pain Relevance 16.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Mgll) lipid particle (Mgll)
Anatomy Link Frequency
BLA 2
spinal 1
midbrain 1
Mgll (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endocannabinoid 101 100.00 Very High Very High Very High
qutenza 53 100.00 Very High Very High Very High
Analgesic 27 99.84 Very High Very High Very High
Inflammation 13 99.84 Very High Very High Very High
aspirin 3 99.84 Very High Very High Very High
analgesia 47 99.28 Very High Very High Very High
amygdala 37 99.14 Very High Very High Very High
agonist 20 98.76 Very High Very High Very High
Pain 24 98.56 Very High Very High Very High
Cannabinoid receptor 15 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 13 99.22 Very High Very High Very High
Pain 11 98.56 Very High Very High Very High
Inflammatory Pain 3 97.96 Very High Very High Very High
Hypersensitivity 9 97.84 Very High Very High Very High
Neurodegenerative Disease 2 97.60 Very High Very High Very High
Urological Neuroanatomy 39 97.40 Very High Very High Very High
Nociception 7 96.24 Very High Very High Very High
Movement Disorders 1 95.84 Very High Very High Very High
Anxiety Disorder 63 95.72 Very High Very High Very High
Neuropathic Pain 19 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this issue, Alvin King, Daniele Piomelli, and colleagues publish another interesting paper on inhibition of monoacylglycerol lipase (MGL).
Negative_regulation (inhibition) of MGL
1) Confidence 0.58 Published 2007 Journal Chem. Biol. Section Abstract Doc Link 18096498 Disease Relevance 0.07 Pain Relevance 0.17
In this issue, Alvin King, Daniele Piomelli, and colleagues publish another interesting paper on inhibition of monoacylglycerol lipase (MGL).
Negative_regulation (inhibition) of monoacylglycerol lipase
2) Confidence 0.58 Published 2007 Journal Chem. Biol. Section Abstract Doc Link 18096498 Disease Relevance 0.07 Pain Relevance 0.17
Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms.
Negative_regulation (Inhibitors) of monoacylglycerol lipase associated with endocannabinoid and qutenza
3) Confidence 0.54 Published 2010 Journal Pharmacol. Res. Section Title Doc Link 20416378 Disease Relevance 0.46 Pain Relevance 1.15
This MiniReview summarizes the literature concerning the potential therapeutic potential of FAAH and MGL inhibitors.
Negative_regulation (inhibitors) of MGL
4) Confidence 0.49 Published 2007 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 17910610 Disease Relevance 0.19 Pain Relevance 0.23
This compound exhibited interesting in vivo analgesic and anti-inflammatory properties, suggesting that selective inhibitors of MGL may be valuable novel agents for the treatment of inflammatory pain.
Negative_regulation (inhibitors) of MGL associated with inflammation, ipn and analgesic
5) Confidence 0.43 Published 2008 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 18819796 Disease Relevance 0.27 Pain Relevance 0.36
Increased tissue 2-AG levels consequent to MGL inhibition are considered therapeutic against pain, inflammation, and neurodegenerative disorders.
Negative_regulation (inhibition) of MGL associated with pain, inflammation and neurodegenerative disease
6) Confidence 0.41 Published 2009 Journal J. Comput. Aided Mol. Des. Section Abstract Doc Link 19543978 Disease Relevance 0.29 Pain Relevance 0.29
The purpose of this review is to give an overview of the families of synthetic inhibitors of FAAH and MAGL.
Negative_regulation (inhibitors) of MAGL
7) Confidence 0.40 Published 2008 Journal Curr Top Med Chem Section Abstract Doc Link 18289091 Disease Relevance 0.09 Pain Relevance 0.14
Our data suggest that 2-AG, the putative product of MGL inhibition, and AEA, the putative product of FAAH inhibition, differentially suppress capsaicin-induced nociception through peripheral cannabinoid mechanisms.
Negative_regulation (inhibition) of MGL associated with nociception, qutenza and cannabinoid
8) Confidence 0.39 Published 2010 Journal Pharmacol. Res. Section Abstract Doc Link 20416378 Disease Relevance 0.48 Pain Relevance 1.23
The compound also inhibited the activity of monoacylglycerol lipase (MGL), the enzyme responsible for the hydrolysis of the endogenous cannabinoid receptor ligand 2-arachidonoylglycerol, with an IC(50) value of 1.9 microM.
Negative_regulation (inhibited) of monoacylglycerol lipase associated with cannabinoid receptor
9) Confidence 0.38 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20143779 Disease Relevance 0.09 Pain Relevance 0.24
The compound also inhibited the activity of monoacylglycerol lipase (MGL), the enzyme responsible for the hydrolysis of the endogenous cannabinoid receptor ligand 2-arachidonoylglycerol, with an IC(50) value of 1.9 microM.
Negative_regulation (inhibited) of MGL associated with cannabinoid receptor
10) Confidence 0.38 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20143779 Disease Relevance 0.09 Pain Relevance 0.24
A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity.
Negative_regulation (inhibitor) of monoacylglycerol lipase associated with inflammation and analgesic
11) Confidence 0.36 Published 2008 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 18819796 Disease Relevance 0.18 Pain Relevance 0.80
Here, we detail a fully refined homology model of MGL which preferentially identifies MGL inhibitors over druglike noninhibitors.
Negative_regulation (inhibitors) of MGL
12) Confidence 0.36 Published 2009 Journal J. Comput. Aided Mol. Des. Section Abstract Doc Link 19543978 Disease Relevance 0.27 Pain Relevance 0.30
By contrast, spinal inhibition of MGL using URB602, which selectively inhibits 2-AG hydrolysis in the PAG, enhanced SIA through a CB1-selective mechanism.
Negative_regulation (inhibition) of MGL in spinal associated with central grey and analgesia
13) Confidence 0.35 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16316669 Disease Relevance 0.43 Pain Relevance 1.41
Inhibition of endocannabinoid transport was more effective in suppressing capsaicin-induced sensitization compared to inhibition of either FAAH or MGL alone.
Negative_regulation (inhibition) of MGL associated with endocannabinoid and qutenza
14) Confidence 0.34 Published 2010 Journal Pharmacol. Res. Section Abstract Doc Link 20416378 Disease Relevance 0.58 Pain Relevance 1.48
Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors.
Negative_regulation (inhibitors) of monoacylglycerol lipase associated with endocannabinoid
15) Confidence 0.34 Published 2008 Journal Curr Top Med Chem Section Title Doc Link 18289091 Disease Relevance 0 Pain Relevance 0.32
A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (K(i) 21.8 microM) without significantly affecting FAAH.
Negative_regulation (inhibits) of MGL
16) Confidence 0.32 Published 2008 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 18819796 Disease Relevance 0.17 Pain Relevance 0.33
FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels.
Negative_regulation (inhibitors) of MAGL associated with endocannabinoid
17) Confidence 0.20 Published 2010 Journal Curr Opin Investig Drugs Section Title Doc Link 20047159 Disease Relevance 0 Pain Relevance 0.50
Inhibition of FAAH or MAGL activity might lead to beneficial effects in many physiological disorders such as pain, inflammation, and anxiety due to increased endocannabinoid-induced activation of cannabinoid receptors CB1 and CB2.
Negative_regulation (Inhibition) of MAGL associated with endocannabinoid, pain, cannabinoid receptor, inflammation and anxiety disorder
18) Confidence 0.18 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17665899 Disease Relevance 0.29 Pain Relevance 0.33
To examine the contribution of endocannabinoids in the BLA to SIA, we used selective pharmacological inhibitors of the anandamide-degrading enzyme fatty-acid amide hydrolase (FAAH) and the 2-arachidonoylglycerol-degrading enzyme monoacylglycerol lipase (MGL).
Negative_regulation (inhibitors) of monoacylglycerol lipase in BLA associated with endocannabinoid, amygdala and analgesia
19) Confidence 0.13 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16378681 Disease Relevance 0.29 Pain Relevance 1.96
To examine the contribution of endocannabinoids in the BLA to SIA, we used selective pharmacological inhibitors of the anandamide-degrading enzyme fatty-acid amide hydrolase (FAAH) and the 2-arachidonoylglycerol-degrading enzyme monoacylglycerol lipase (MGL).
Negative_regulation (inhibitors) of MGL in BLA associated with endocannabinoid, amygdala and analgesia
20) Confidence 0.13 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16378681 Disease Relevance 0.29 Pain Relevance 1.97

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