INT131883

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.41
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
alveolar macrophages 1
lungs 1
spinal cord dorsal horn 1
gr (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 13 100.00 Very High Very High Very High
Spinal cord 3 100.00 Very High Very High Very High
Dorsal horn 2 100.00 Very High Very High Very High
Hippocampus 7 96.00 Very High Very High Very High
intrathecal 3 93.80 High High
depression 6 89.60 High High
antagonist 1 82.48 Quite High
Inflammatory response 48 79.20 Quite High
nMDA receptor 2 75.00 Quite High
corticosteroid 15 73.72 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 20 96.14 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 216 95.70 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 5 94.36 High High
Depression 6 89.60 High High
Disease 68 84.88 Quite High
INFLAMMATION 164 78.84 Quite High
Asthma 22 73.68 Quite High
Stress 48 69.92 Quite High
Aggression 13 52.24 Quite High
Congenital Anomalies 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GSK-3 has been shown to phosphorylate and inhibit GR [99].
Phosphorylation (phosphorylate) of GR
1) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.37 Pain Relevance 0.37
The expression of p38 mitogen-activated protein kinase (MAPK) is elevated in the peripheral lungs and alveolar macrophages in patients with mild or moderate COPD compared with smokers.90 This study also suggested an inverse correlation between the activation of p38 MAPK and the reduction in FEV1 and FEV1/FVC.90 An elevation of p38 MAPK may be responsible for an increase in phosphorylation of GR?
Phosphorylation (phosphorylation) of GR in lungs associated with nicotine addiction and chronic obstructive pulmonary disease
2) Confidence 0.10 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.02 Pain Relevance 0.11
Moreover, the expression of phosphorylated CREB was upregulated within the spinal cord dorsal horn after chronic morphine, and a CREB antisense oligodeoxynucleotide coadministered intrathecally with morphine prevented the upregulation of GR, NR1, and PKCgamma.
Phosphorylation (phosphorylated) of GR in spinal cord dorsal horn associated with dorsal horn, morphine and spinal cord
3) Confidence 0.04 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.55
The expression of p38 mitogen-activated protein kinase (MAPK) is elevated in the peripheral lungs and alveolar macrophages in patients with mild or moderate COPD compared with smokers.90 This study also suggested an inverse correlation between the activation of p38 MAPK and the reduction in FEV1 and FEV1/FVC.90 An elevation of p38 MAPK may be responsible for an increase in phosphorylation of GR?
Phosphorylation (phosphorylation) of GR in alveolar macrophages associated with nicotine addiction and chronic obstructive pulmonary disease
4) Confidence 0.03 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.02 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox