INT131884

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.31
Pain Relevance 6.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
spinal cord dorsal horn 4
spinal 2
gr (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 99 99.60 Very High Very High Very High
Morphine 26 99.20 Very High Very High Very High
Neuropeptide 27 99.08 Very High Very High Very High
Spinal cord 46 98.48 Very High Very High Very High
Dorsal horn 19 97.20 Very High Very High Very High
Pain 60 95.52 Very High Very High Very High
Calcitonin gene-related peptide 96 93.68 High High
substance P 87 93.44 High High
Somatostatin 63 93.28 High High
spinal dorsal horn 33 91.96 High High
Disease Link Frequency Relevance Heat
Stress 36 99.86 Very High Very High Very High
Nociception 75 98.04 Very High Very High Very High
Pain 69 95.52 Very High Very High Very High
Hyperalgesia 3 75.32 Quite High
Polycystic Ovary Syndrome 21 22.80 Low Low
Urological Neuroanatomy 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic morphine (10 microg, i.t.; twice daily for 6 d) induced a time-dependent upregulation of GR, the NR1 subunit of NMDAR, and PKCgamma within the rat's spinal cord dorsal horn.
Positive_regulation (induced) of Positive_regulation (upregulation) of GR in spinal cord dorsal horn associated with dorsal horn, spinal cord and morphine
1) Confidence 0.03 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.14
Chronic morphine (10 microg, i.t.; twice daily for 6 d) induced a time-dependent upregulation of GR, the NR1 subunit of NMDAR, and PKCgamma within the rat's spinal cord dorsal horn.
Positive_regulation (time-dependent) of Positive_regulation (upregulation) of GR in spinal cord dorsal horn associated with dorsal horn, spinal cord and morphine
2) Confidence 0.03 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.14
In basal conditions, MR display greater occupancy than GR; thus, conditions resulting in elevation of corticosteroids, e.g. stress, will result mainly in increased activation of GR.
Positive_regulation (increased) of Positive_regulation (activation) of GR associated with stress and corticosteroid
3) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.83 Pain Relevance 1.20
In the premise that a distinctive activation of MR or GR could be responsible for altered levels of neuropeptides involved in spinal nociceptive transmission and, consequently, for diverse pain-like effects we evaluated the density of CGRP, SP, SS and GABAB2 innervation in the spinal dorsal horn of animals submitted to prolonged administration of CORT (activating both MR and GR) and DEX (a selective ligand of GR).
Positive_regulation (responsible) of Positive_regulation (activation) of GR in spinal associated with nociception, pain, spinal dorsal horn, somatostatin, calcitonin gene-related peptide, neuropeptide, dexamethasone and substance p
4) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.64 Pain Relevance 1.35
In basal conditions, MR display greater occupancy than GR; thus, conditions resulting in elevation of corticosteroids, e.g. stress, will result mainly in increased activation of GR.
Positive_regulation (result) of Positive_regulation (activation) of GR associated with stress and corticosteroid
5) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.84 Pain Relevance 1.20

General Comments

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