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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Creb1, Prkcg) nucleoplasm (Creb1) mitochondrion (Creb1)
intracellular (Prkcg) DNA binding (Creb1) response to stress (Prkcg)
Anatomy Link Frequency
spinal 2
Creb1 (Rattus norvegicus)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 13 99.40 Very High Very High Very High
Dorsal horn 2 91.48 High High
Spinal cord 2 91.00 High High
tolerance 2 84.72 Quite High
intrathecal 3 82.48 Quite High
nMDA receptor 2 75.00 Quite High
antagonist 1 71.16 Quite High
Kinase C 1 43.20 Quite Low


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that spinal GR through the cAMP-CREB pathway played a significant role in NMDAR and PKCgamma expression after chronic morphine exposure.
cAMP-CREB Positive_regulation (role) of Gene_expression (expression) of PKCgamma in spinal associated with morphine
1) Confidence 0.03 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.31

General Comments

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