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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.02
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcna6)
Anatomy Link Frequency
neuronal 1
soma 1
Kcna6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 1 99.22 Very High Very High Very High
Neuronal excitability 3 99.16 Very High Very High Very High
ischemia 14 97.68 Very High Very High Very High
hyperexcitability 3 95.32 Very High Very High Very High
Action potential 7 93.96 High High
midbrain 2 84.24 Quite High
Dopamine 3 83.52 Quite High
Pyramidal cell 5 62.68 Quite High
potassium channel 3 62.16 Quite High
Central nervous system 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 1 99.56 Very High Very High Very High
Cv Unclassified Under Development 13 97.68 Very High Very High Very High
Alzheimer's Dementia 4 97.28 Very High Very High Very High
Stroke 2 97.28 Very High Very High Very High
Drug Induced Neurotoxicity 1 95.96 Very High Very High Very High
Hypoxia 10 94.96 High High
Convulsion 2 94.32 High High
Neuroblastoma 1 93.84 High High
Disease 17 88.88 High High
Apoptosis 166 78.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia.
Regulation (modulation) of Kv2 in neuronal associated with anesthesia, neuronal excitability and ischemia
1) Confidence 0.20 Published 2005 Journal J. Neurosci. Section Title Doc Link 16319318 Disease Relevance 0.93 Pain Relevance 0.54
Since transfected Kv2.1 initially localizes to the AIS before appearing on the soma, it is likely multiple mechanisms regulate Kv2.1 trafficking to the cell surface.

Spec (likely) Regulation (regulate) of Kv2 in soma
2) Confidence 0.16 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2592246 Disease Relevance 0.06 Pain Relevance 0.08
Up-regulation of Kv1.4, Kv2.1 and Kv4.2 expression both mRNA and protein levels is observed in amyloid peptide (25-35) -induced neurotoxicity [103].
Regulation (regulation) of Kv2 associated with drug induced neurotoxicity and alzheimer's dementia
3) Confidence 0.11 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 1.03 Pain Relevance 0.15

General Comments

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