INT1319

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Context Info
Confidence 0.78
First Reported 1976
Last Reported 2009
Negated 3
Speculated 1
Reported most in Abstract
Documents 65
Total Number 66
Disease Relevance 9.34
Pain Relevance 42.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 8
spinal cord 4
hippocampus 2
spinal 2
POA 2
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 180 100.00 Very High Very High Very High
opioid receptor 117 100.00 Very High Very High Very High
Opioid 73 100.00 Very High Very High Very High
opiate 66 100.00 Very High Very High Very High
antagonist 63 100.00 Very High Very High Very High
agonist 56 100.00 Very High Very High Very High
narcan 46 100.00 Very High Very High Very High
Kappa opioid receptor 36 100.00 Very High Very High Very High
Analgesic 20 100.00 Very High Very High Very High
Spinal cord 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 8 99.64 Very High Very High Very High
Targeted Disruption 37 99.34 Very High Very High Very High
Thymoma 2 99.20 Very High Very High Very High
Respiratory Failure 2 98.84 Very High Very High Very High
Neuroblastoma 2 98.80 Very High Very High Very High
Pruritus 4 98.68 Very High Very High Very High
Bordatella Infection 4 98.48 Very High Very High Very High
Ganglion Cysts 2 98.48 Very High Very High Very High
Appetite Loss 3 97.28 Very High Very High Very High
Aggression 2 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of opioid receptor-like 1 (ORL1) & mu opioid receptors in the spinal cord of morphine tolerant mice.
Gene_expression (Expression) of opioid receptor-like 1 in spinal cord associated with mu opioid receptor, opioid receptor, morphine and spinal cord
1) Confidence 0.78 Published 2005 Journal Indian J. Med. Res. Section Title Doc Link 15802762 Disease Relevance 0 Pain Relevance 0.85
Expression of opioid receptor-like 1 (ORL1) & mu opioid receptors in the spinal cord of morphine tolerant mice.
Gene_expression (Expression) of ORL1 in spinal cord associated with mu opioid receptor, opioid receptor, morphine and spinal cord
2) Confidence 0.78 Published 2005 Journal Indian J. Med. Res. Section Title Doc Link 15802762 Disease Relevance 0 Pain Relevance 0.85
An increased expression of ORL1 receptors was also noted over the gray matter around the central canal.
Gene_expression (expression) of ORL1 in central canal
3) Confidence 0.78 Published 2005 Journal Indian J. Med. Res. Section Body Doc Link 15802762 Disease Relevance 0 Pain Relevance 0
INTERPRETATION & CONCLUSION: The present study showed that both, ORL1 and mu-opioid receptors were expressed in areas of the spinal cord, concerned with transmission of pain signals.
Gene_expression (expressed) of ORL1 in spinal cord
4) Confidence 0.78 Published 2005 Journal Indian J. Med. Res. Section Body Doc Link 15802762 Disease Relevance 0 Pain Relevance 0
No significant alterations in ORL1 receptor expression were observed across brain regions in mu-receptor knockout mice and there were no qualitative differences in ORL1 receptor expression in any groups.
Gene_expression (expression) of ORL1 in brain associated with targeted disruption
5) Confidence 0.78 Published 2001 Journal Neuroscience Section Abstract Doc Link 11591451 Disease Relevance 0.24 Pain Relevance 0.29
No significant alterations in ORL1 receptor expression were observed across brain regions in mu-receptor knockout mice and there were no qualitative differences in ORL1 receptor expression in any groups.
Gene_expression (expression) of ORL1 in brain associated with targeted disruption
6) Confidence 0.78 Published 2001 Journal Neuroscience Section Abstract Doc Link 11591451 Disease Relevance 0.25 Pain Relevance 0.30
In contrast, ORL1 receptor expression was down-regulated in virtually all brain structures in heterozygous kappa-knockouts although the magnitude of this change was not as great as for the delta-knockouts.
Gene_expression (expression) of ORL1 in brain structures
7) Confidence 0.78 Published 2001 Journal Neuroscience Section Abstract Doc Link 11591451 Disease Relevance 0.24 Pain Relevance 0.31
An up-regulation of ORL1 expression was observed across all brain regions in delta-knockouts with cortical regions typically showing a 15-30% increase in binding that was most marked in heterozygous mice.
Gene_expression (expression) of ORL1 in brain
8) Confidence 0.78 Published 2001 Journal Neuroscience Section Abstract Doc Link 11591451 Disease Relevance 0.23 Pain Relevance 0.30
To determine if the behavioural phenotype of nociceptin/orphanin FQ knockout mice reflects changes in either opioid receptor-like 1 or classical opioid receptor expression, we have carried out quantitative autoradiography of the opioid receptor-like 1, mu-, delta- and kappa-opioid receptors in the brains of these animals.
Gene_expression (expression) of opioid receptor-like in brains associated with targeted disruption, orphanin, kappa opioid receptor and opioid receptor
9) Confidence 0.77 Published 2003 Journal Neuroscience Section Abstract Doc Link 12605902 Disease Relevance 0.69 Pain Relevance 1.74
Histological analysis revealed the expression of both the nociceptin precursor and the nociceptin receptor in the hippocampus, thought to take part in aspects of learning and memory.
Gene_expression (expression) of nociceptin receptor in hippocampus associated with orphanin and hippocampus
10) Confidence 0.76 Published 1998 Journal Nature Section Abstract Doc Link 9707118 Disease Relevance 0.26 Pain Relevance 0.71
Histological analysis revealed the expression of both the nociceptin precursor and the nociceptin receptor in the hippocampus, thought to take part in aspects of learning and memory.
Gene_expression (expression) of nociceptin precursor in hippocampus associated with orphanin and hippocampus
11) Confidence 0.76 Published 1998 Journal Nature Section Abstract Doc Link 9707118 Disease Relevance 0.26 Pain Relevance 0.70
Mu and ORL1 receptor expression were not altered significantly.
Gene_expression (expression) of ORL1
12) Confidence 0.76 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12417646 Disease Relevance 0.57 Pain Relevance 0.97
In vitro, J-113397 inhibited nociceptin/orphanin FQ-stimulated [35S]guanosine 5'-O-(gamma-thio)triphosphate (GTP gamma S) binding to Chinese Hamster Ovary (CHO) cells expressing ORL1 (CHO-ORL1) with an IC(50) value of 5.3 nM but had no effect on [35S]GTP gamma S binding by itself.
Gene_expression (expressing) of ORL1 in CHO associated with orphanin
13) Confidence 0.75 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940356 Disease Relevance 0.06 Pain Relevance 0.48
Continuous exposure of COS-7 cells expressing the kappa receptor to the agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide methanesulfonate salt (U50,488) reduces the specific binding of the kappa-selective agonist [3H]U69,593.
Gene_expression (expressing) of kappa receptor associated with agonist
14) Confidence 0.75 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932192 Disease Relevance 0 Pain Relevance 0.80
Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene.
Gene_expression (mapping) of ORL1 in brains associated with targeted disruption
15) Confidence 0.68 Published 2001 Journal Brain Res. Section Title Doc Link 11430857 Disease Relevance 0.18 Pain Relevance 0.41
The uptake was maximal in lung where the kappa receptor is largely expressed. [(11)C]-MeJDTic rapidly crossed the blood-brain barrier and accumulated in the brain regions of interest (hypothalamus).
Gene_expression (expressed) of kappa receptor in brain
16) Confidence 0.67 Published 2008 Journal Nucl. Med. Biol. Section Body Doc Link 18589300 Disease Relevance 0 Pain Relevance 0
In proenkephalin knockouts this was most pronounced for the micro- and delta-receptor and in prodynorphin knockouts for the kappa-receptor.
Gene_expression (pronounced) of kappa-receptor
17) Confidence 0.67 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614912 Disease Relevance 0.21 Pain Relevance 0.56
Prepronociceptin and ORL1 receptor mRNAs were substantially expressed in the skin, whereas their expression levels were very low in the dorsal root ganglia.
Gene_expression (expressed) of ORL1 receptor in dorsal root ganglia
18) Confidence 0.67 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15191560 Disease Relevance 0.22 Pain Relevance 0.64
The results suggest that nociceptin acts on ORL1 receptor on the keratinocytes to produce leukotriene B(4), which induces itch-associated responses in mice.
Gene_expression (produce) of ORL1 receptor in keratinocytes associated with orphanin and pruritus
19) Confidence 0.67 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15191560 Disease Relevance 0.29 Pain Relevance 0.56
Further, experiments on cultured cells transfected with nociceptin receptor cDNA show that NalBzoH competes [3H]-nociceptin binding and attenuates the nociceptin-induced inhibition of cAMP accumulation induced by forskolin.
Gene_expression (transfected) of nociceptin receptor cDNA associated with orphanin
20) Confidence 0.67 Published 1999 Journal Brain Res. Section Abstract Doc Link 10612708 Disease Relevance 0.15 Pain Relevance 0.73

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