INT13190

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Context Info
Confidence 0.31
First Reported 1981
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.97
Pain Relevance 4.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Pbk) cellular_component (Pbk)
Anatomy Link Frequency
lymphocyte 1
T-helper cells 1
peritoneal macrophages 1
T cells 1
Pbk (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 26 99.82 Very High Very High Very High
opiate 12 99.20 Very High Very High Very High
narcan 7 99.00 Very High Very High Very High
antagonist 4 98.92 Very High Very High Very High
Analgesic 4 98.80 Very High Very High Very High
Opioid 3 97.64 Very High Very High Very High
Enkephalin 4 96.76 Very High Very High Very High
Neuropeptide 2 93.88 High High
agonist 4 93.76 High High
Inflammation 4 90.72 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 5 98.18 Very High Very High Very High
Infection 3 97.12 Very High Very High Very High
Vesicular Stomatitis 2 96.64 Very High Very High Very High
INFLAMMATION 6 90.72 High High
Bacterial Infection 3 89.40 High High
Experimental Arthritis 1 79.92 Quite High
Body Weight 1 79.76 Quite High
Arthus Reaction 1 76.96 Quite High
Necrosis 2 75.00 Quite High
Cancer 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The compound had no activity against certain in vitro correlates of delayed hypersensitivity reactions (lymphocyte transformation and lymphokine activity), but did have an inhibitory effect on lymphokine (MIF) productions at 10(-4) M but not at 10(-5) M.
Gene_expression (productions) of lymphokine in lymphocyte associated with hypersensitivity
1) Confidence 0.31 Published 1981 Journal Agents Actions Section Abstract Doc Link 6456651 Disease Relevance 0.86 Pain Relevance 0.25
We report here on the effect of morphine sulfate (MS) (0.2-1.6 mM) on Concanavalin-A (Con-A) stimulated lymphokine production by mouse splenocytes in vitro.
Gene_expression (production) of lymphokine associated with morphine
2) Confidence 0.13 Published 1991 Journal Immunopharmacology Section Abstract Doc Link 1663496 Disease Relevance 0 Pain Relevance 0.61
The inhibitory effect of MS on lymphokine production was not blocked by opiate antagonists nor was the inhibitory effect mimicked by equivalent concentrations of mu, delta or epsilon receptor-specific opiate agonists.
Gene_expression (production) of lymphokine associated with antagonist, agonist and opiate
3) Confidence 0.13 Published 1991 Journal Immunopharmacology Section Abstract Doc Link 1663496 Disease Relevance 0 Pain Relevance 0.78
Twenty-four hour incubation of mouse splenocytes with MS, removal of the drug and activation with Con-A resulted in a significant (linear regression, P less than 0.001) dose-related inhibition of lymphokine production (IC50 = 0.8 mM) as measured by bioassay for interleukin-2 (IL-2)/interleukin-4 (IL-4).
Gene_expression (production) of lymphokine
4) Confidence 0.13 Published 1991 Journal Immunopharmacology Section Abstract Doc Link 1663496 Disease Relevance 0 Pain Relevance 0.70
Effect of high doses of morphine on Con-A induced lymphokine production in vitro.
Gene_expression (production) of lymphokine associated with narcan and morphine
5) Confidence 0.13 Published 1991 Journal Immunopharmacology Section Title Doc Link 1663496 Disease Relevance 0 Pain Relevance 0.76
One day prior to sublethal infection, balb/c mice were treated intravenously with various therapeutic concentrations of ibuprofen alone or ibuprofen in combination with a suboptimal dosage of murine recombinant interferon gamma, a lymphokine produced by T-helper cells.
Gene_expression (produced) of lymphokine in T-helper cells associated with infection
6) Confidence 0.04 Published 1995 Journal Arzneimittelforschung Section Abstract Doc Link 7893261 Disease Relevance 0.67 Pain Relevance 0.18
AIM: To study the influence of morphine on lymphokine production from mouse peritoneal macrophages (PM phi).
Gene_expression (production) of lymphokine in peritoneal macrophages associated with morphine
7) Confidence 0.01 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 8701766 Disease Relevance 0.15 Pain Relevance 0.17
Regulation of lymphokine (gamma-interferon) production by corticotropin.
Gene_expression (production) of lymphokine
8) Confidence 0.01 Published 1984 Journal J. Immunol. Section Title Doc Link 6317743 Disease Relevance 0 Pain Relevance 0.18
Identification of distinct sites of beta-endorphin that stimulate lymphokine production by murine CD4+ T cells.
Gene_expression (production) of lymphokine in T cells associated with narcan
9) Confidence 0.01 Published 1994 Journal Lymphokine Cytokine Res. Section Title Doc Link 7914752 Disease Relevance 0 Pain Relevance 0.48
Lymphokine expression profile of resting and stimulated CD4+ CTL clones specific for the glycoprotein of vesicular stomatitis virus.
Gene_expression (expression) of Lymphokine associated with vesicular stomatitis
10) Confidence 0.01 Published 1993 Journal Cell. Immunol. Section Title Doc Link 8381052 Disease Relevance 0.29 Pain Relevance 0.04

General Comments

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