INT131916

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 9.33
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ALPL) plasma membrane (ALPL)
Anatomy Link Frequency
plasma 1
teeth 1
ALPL (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 8 97.48 Very High Very High Very High
backache 8 96.00 Very High Very High Very High
cINOD 79 92.84 High High
Pain 77 91.04 High High
Inflammation 122 89.36 High High
Analgesic 7 77.32 Quite High
cytokine 1 53.20 Quite High
Arthritis 3 39.44 Quite Low
peripheral neuropathy 1 13.20 Low Low
imagery 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.96 Very High Very High Very High
Phosphate Metabolism Disorders 301 99.36 Very High Very High Very High
Osteomyelitis 80 98.80 Very High Very High Very High
Hypophosphatasia 96 97.66 Very High Very High Very High
Malignant Neoplastic Disease 41 97.40 Very High Very High Very High
Low Back Pain 8 96.00 Very High Very High Very High
Disease 68 92.92 High High
Prostate Cancer 112 92.00 High High
Injury 24 91.52 High High
Pain 79 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, it has been shown in mice that inactivation of the Pc-1 gene in TNAP-knock-out mice allows to restore the normal bone phenotype [17].
Negative_regulation (inactivation) of TNAP associated with targeted disruption
1) Confidence 0.42 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2164941 Disease Relevance 0.67 Pain Relevance 0.07
Hypophosphatasia (OMIM 146300, 241500, 241510) is an inherited disorder characterized by defective bone and teeth mineralization and deficiency of serum and bone alkaline phosphatase (AP) activity.


Negative_regulation (deficiency) of bone alkaline phosphatase in teeth associated with hypophosphatasia
2) Confidence 0.42 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2164941 Disease Relevance 0.69 Pain Relevance 0
Thus, this study provides evidence that the elevation of PGs in HP might be based on the impaired clearance of calcium pyrophosphate resulting from alkaline phosphatase deficiency.
Negative_regulation (deficiency) of alkaline associated with phosphate metabolism disorders
3) Confidence 0.41 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.74 Pain Relevance 0.17
Hypophosphatasia (HP) (MIM 241510) is an inborn error of bone metabolism, characterized by a genetic defect in the gene encoding the tissue-nonspecific alkaline phosphatase (TNSALP) [1-3].
Negative_regulation (defect) of TNSALP associated with phosphate metabolism disorders
4) Confidence 0.41 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.48 Pain Relevance 0.09
Hypophosphatasia (HP) is an inborn error of bone metabolism characterized by a genetic defect in the gene encoding the tissue-nonspecific alkaline phosphatase (TNSALP).
Negative_regulation (defect) of TNSALP associated with phosphate metabolism disorders
5) Confidence 0.41 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1533806 Disease Relevance 0.68 Pain Relevance 0.31
Hypophosphatasia (HP) is characterized by a genetic defect in the tissue-nonspecific alkaline phosphatase (TNSALP) gene and predominantly an autosomal recessive trait.
Negative_regulation (defect) of TNSALP associated with phosphate metabolism disorders
6) Confidence 0.36 Published 2007 Journal BMC Pediatr Section Abstract Doc Link PMC1784091 Disease Relevance 0.85 Pain Relevance 0.12
We suggested that a partial defect in the TNSALP gene was present.
Spec (partial) Negative_regulation (defect) of TNSALP gene
7) Confidence 0.36 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC1784091 Disease Relevance 0.69 Pain Relevance 0.09
The diagnostic tests related to growth failure were repeated and subsequent analyses demonstrated a molecular defect in the TNSALP gene.
Negative_regulation (defect) of TNSALP gene
8) Confidence 0.36 Published 2007 Journal BMC Pediatr Section Abstract Doc Link PMC1784091 Disease Relevance 1.63 Pain Relevance 0.30
Visual Analogue Scale improvement was positively correlated with decrease of C-telopeptide and bone phosphatase alkaline (p<0.05) serum levels.
Negative_regulation (decrease) of bone phosphatase
9) Confidence 0.33 Published 2005 Journal J Chemother Section Abstract Doc Link 16323446 Disease Relevance 0.50 Pain Relevance 0.30
Further analyses did show a decreased TNSALP in leukocytes and elevated pyridoxal phosphate in plasma, suggesting a heterozygous carrier status of HP.


Negative_regulation (decreased) of TNSALP in plasma associated with phosphate metabolism disorders
10) Confidence 0.31 Published 2007 Journal BMC Pediatr Section Abstract Doc Link PMC1784091 Disease Relevance 1.79 Pain Relevance 0.32
Nearly half of the patients showed a decrease in both the markers of bone metabolism (n-telopeptide and bone alkaline phosphatase) by week 12.
Negative_regulation (decrease) of bone alkaline phosphatase
11) Confidence 0.04 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.61 Pain Relevance 0.03

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