INT131925

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.66
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (COX1) mitochondrion (COX1) oxidoreductase activity (COX1)
aging (COX1) molecular_function (COX1)
Anatomy Link Frequency
substantia nigra pars reticulata 1
subthalamic nucleus 1
COX1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Substantia nigra 4 96.40 Very High Very High Very High
Glutamate receptor 4 75.00 Quite High
projection neuron 6 70.40 Quite High
Dopamine 21 63.52 Quite High
antagonist 2 42.24 Quite Low
Enkephalin 3 25.00 Low Low
Neuropeptide 3 25.00 Low Low
positron emission tomography 5 5.00 Very Low Very Low Very Low
Thalamus 5 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 43 98.96 Very High Very High Very High
Wheal 1 95.32 Very High Very High Very High
Parkinson's Disease 27 82.88 Quite High
Dyskinesias 43 7.60 Low Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Hypokinesia 2 5.00 Very Low Very Low Very Low
Dystonia 2 5.00 Very Low Very Low Very Low
Chorea 1 5.00 Very Low Very Low Very Low
Tremor 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intraneuronal gene expression of cytochrome oxidase subunit I (COI), a metabolic index of neuronal activity, was increased in the subthalamic nucleus, substantia nigra pars reticulata and decreased in frontal cortical areas, but paradoxically unchanged in the striatum, globus pallidus, entopeduncular nucleus and ventrolateral thalamic nucleus.
Gene_expression (expression) of oxidase subunit I in subthalamic nucleus associated with substantia nigra
1) Confidence 0.54 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16324110 Disease Relevance 0.17 Pain Relevance 0.18
Intraneuronal gene expression of cytochrome oxidase subunit I (COI), a metabolic index of neuronal activity, was increased in the subthalamic nucleus, substantia nigra pars reticulata and decreased in frontal cortical areas, but paradoxically unchanged in the striatum, globus pallidus, entopeduncular nucleus and ventrolateral thalamic nucleus.
Gene_expression (expression) of oxidase subunit I in substantia nigra pars reticulata associated with substantia nigra
2) Confidence 0.18 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16324110 Disease Relevance 0.17 Pain Relevance 0.18
The enzymatic activity or the changes in the expression of cytochrome oxidase-I (COI) have indeed been shown to correlate with changes in the firing activity of several structures (Wong-Riley and Welt, 1980; Wong-Riley, 1989).
Gene_expression (expression) of cytochrome oxidase-I associated with wheal
3) Confidence 0.11 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.31 Pain Relevance 0

General Comments

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