INT131928

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Context Info
Confidence 0.74
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.22
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
blood 1
Il1rn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 98.24 Very High Very High Very High
Thermal hyperalgesia 3 97.40 Very High Very High Very High
antidepressant 20 97.20 Very High Very High Very High
allodynia 3 96.04 Very High Very High Very High
Inflammation 13 94.64 High High
intrathecal 2 88.28 High High
cytokine 7 86.32 High High
Osteoarthritis 42 83.20 Quite High
Pain 31 78.96 Quite High
chemokine 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Necrosis 2 98.40 Very High Very High Very High
Cancer 2 98.04 Very High Very High Very High
Hyperalgesia 3 97.40 Very High Very High Very High
Neuropathic Pain 3 96.04 Very High Very High Very High
INFLAMMATION 14 94.64 High High
Osteoarthritis 20 83.20 Quite High
Disease 13 82.64 Quite High
Pain 26 78.96 Quite High
Arthritis 2 72.64 Quite High
Arthralgia 5 72.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding is in line with the results from Kubera and colleagues (2000), who reported that IL-1Ra was elevated in depressed patients and did not normalize after response following antidepressant treatment.
Localization (elevated) of IL-1Ra associated with antidepressant
1) Confidence 0.74 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515903 Disease Relevance 0.22 Pain Relevance 0.36
Microglial activation appears to lead to the release of IL1, given that pretreatment with IL1 receptor antagonist blocked both fractalkine-induced mechanical allodynia and thermal hyperalgesia.
Localization (release) of IL1 associated with allodynia, thermal hyperalgesia and antagonist
2) Confidence 0.48 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16324111 Disease Relevance 0.99 Pain Relevance 1.38
and interleukin 1 (IL1) release from human blood buffy coat cells than the inhibition seen with each of the single agents alone.20 Similarly, in the rat model of lipopolysaccharide (LPS)-induced TNF?
Localization (release) of IL1 in blood
3) Confidence 0.08 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564788 Disease Relevance 1.01 Pain Relevance 0.50

General Comments

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