INT131929

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 12.61
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (S100B) extracellular region (S100B) nucleus (S100B)
cytoplasm (S100B)
Anatomy Link Frequency
astrocytes 8
brain 6
urine 2
S100B (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 180 99.80 Very High Very High Very High
depression 57 98.70 Very High Very High Very High
fluoxetine 19 97.16 Very High Very High Very High
sodium channel 1 97.12 Very High Very High Very High
sSRI 18 96.92 Very High Very High Very High
cytokine 17 95.40 Very High Very High Very High
Inflammation 190 88.04 High High
bDMF 20 82.56 Quite High
Pain 5 77.64 Quite High
Central nervous system 13 74.40 Quite High
Disease Link Frequency Relevance Heat
Depression 226 99.84 Very High Very High Very High
Neurodegenerative Disease 29 99.44 Very High Very High Very High
Encephalopathy 180 99.40 Very High Very High Very High
Syndrome 142 99.28 Very High Very High Very High
Respiratory Failure 5 98.28 Very High Very High Very High
Appetite Loss 3 98.12 Very High Very High Very High
Apoptosis 40 97.04 Very High Very High Very High
Sepsis 190 96.64 Very High Very High Very High
Obesity 93 96.20 Very High Very High Very High
Disease 28 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Our data suggest a direct relation between childhood migraine attacks and increased production of glial S100beta protein.
Positive_regulation (increased) of Gene_expression (production) of S100beta
1) Confidence 0.67 Published 2005 Journal Headache Section Body Doc Link 16324163 Disease Relevance 0.07 Pain Relevance 0
The selective serotonin reuptake inhibitor (SSRI) fluoxetine, which is registered for a variety of psychiatric disorders, has been found to stimulate the cAMP-responsive element binding protein (CREB), increase the production of brain-derived neurotrophic factor (BNDF) and the neurotrophic peptide S100beta, enhance glycogenolysis in astrocytes, block voltage-gated calcium and sodium channels, and decrease the conductance of mitochondrial voltage-dependent anion channels (VDACs).
Positive_regulation (increase) of Gene_expression (production) of S100beta in astrocytes associated with sodium channel, ssri and fluoxetine
2) Confidence 0.49 Published 2008 Journal CNS neuroscience & therapeutics Section Abstract Doc Link 18482027 Disease Relevance 0.43 Pain Relevance 0.61
This fact might explain on one hand, the low S100B levels in mothers, and on the other, the gradual increase of S100B levels from N1 to N4.
Positive_regulation (increase) of Gene_expression (levels) of S100B
3) Confidence 0.48 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 0.39 Pain Relevance 0
This fact might explain on one hand, the low S100B levels in mothers, and on the other, the gradual increase of S100B levels from N1 to N4.
Positive_regulation (increase) of Gene_expression (levels) of S100B
4) Confidence 0.48 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 0.38 Pain Relevance 0
Besides, S100B positive-astrocytes located in the ipsilateral side showed an increase in their arborization, but not in the level of expression of the S100B protein.
Positive_regulation (increase) of Gene_expression (expression) of S100B in astrocytes
5) Confidence 0.47 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20043976 Disease Relevance 0.40 Pain Relevance 0.23
Prior studies have shown that cardiothoracic surgeries resulted in higher serum levels of S100B.
Positive_regulation (resulted) of Gene_expression (levels) of S100B
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 1.09 Pain Relevance 0.03
Similarly, Western blot measurements revealed that brain tissue expressed high levels of S100B but comparable levels were found in skeletal muscle.
Positive_regulation (levels) of Gene_expression (expressed) of S100B in brain
7) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2937027 Disease Relevance 0.66 Pain Relevance 0.03
Our attempt to control the increased levels of S100B caused by contamination from the surgical field did not yield different results.
Positive_regulation (increased) of Gene_expression (levels) of S100B
8) Confidence 0.47 Published 2004 Journal BMC Neurol Section Abstract Doc Link PMC544890 Disease Relevance 0.11 Pain Relevance 0
Our attempt to control the increased levels of S100B caused by contamination from the surgical field did not yield different results.
Positive_regulation (caused) of Gene_expression (levels) of S100B
9) Confidence 0.47 Published 2004 Journal BMC Neurol Section Abstract Doc Link PMC544890 Disease Relevance 0.11 Pain Relevance 0
Alternatively, Florio et al. documented increased levels of S100B in urine samples from IUGR neonates, with highest levels in those with abnormal neurological outcome [62].
Positive_regulation (increased) of Gene_expression (levels) of S100B in urine
10) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 0.30 Pain Relevance 0
There are two causes of increased serum S100B levels, brain damage,29 and functional secretion by astrocytes.30 Mathematical models suggest that serum S100B levels above 350 ng/L indicate brain damage.31 In our study, the serum S100B levels were lower than 350 ng/L, which indicates that the levels observed in this study reflect functional secretion by astrocytes.
Positive_regulation (increased) of Gene_expression (levels) of S100B in astrocytes
11) Confidence 0.44 Published 2008 Journal Psychiatry Investigation Section Body Doc Link PMC2796025 Disease Relevance 0.23 Pain Relevance 0.26
Serum S100B levels
Positive_regulation (Serum) of Gene_expression (levels) of S100B
12) Confidence 0.44 Published 2008 Journal Psychiatry Investigation Section Body Doc Link PMC2796025 Disease Relevance 0.42 Pain Relevance 0.45
Thereafter a subsequent decrease was observed during the rest of the study period, except in one patient in whom the concentration of S100B increased to 2,0 ?
Positive_regulation (concentration) of Gene_expression (concentration) of S100B
13) Confidence 0.44 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.08 Pain Relevance 0
Thereafter a subsequent decrease was observed during the rest of the study period, except in one patient in whom the concentration of S100B increased to 2,0 ?
Neg (except) Positive_regulation (increased) of Gene_expression (concentration) of S100B
14) Confidence 0.44 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.08 Pain Relevance 0
Neuroplasticity is disrupted in depression.3 In response, the brain attempts to restore neuroplasticity by increasing the S100B levels in depressive patients.19 However, the compensatory mechanism varies among depressive patients.19 As a result, some depressive patients have high concentrations of S100B, while others have low concentrations.
Positive_regulation (increasing) of Gene_expression (levels) of S100B in brain associated with depression
15) Confidence 0.39 Published 2008 Journal Psychiatry Investigation Section Body Doc Link PMC2796025 Disease Relevance 0.97 Pain Relevance 0.19
Furthermore, in the present study patients with high baseline serum S100B levels were clinically improved within 6 weeks of treatment with antidepressants, but the increases in their serum S100B levels during 6 weeks of antidepressant treatment were minimal.
Positive_regulation (increases) of Gene_expression (levels) of S100B associated with antidepressant
16) Confidence 0.39 Published 2008 Journal Psychiatry Investigation Section Body Doc Link PMC2796025 Disease Relevance 0.25 Pain Relevance 0.66
Patients with a GCS <13 had significantly higher APACHE II scores, baseline SOFA scores and higher baseline S100B values than those with a GCS ?
Positive_regulation (higher) of Gene_expression (values) of baseline S100B
17) Confidence 0.38 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 0 Pain Relevance 0
S100B levels were increased in 42% of patients, exceeding 1 ?
Positive_regulation (increased) of Gene_expression (levels) of S100B
18) Confidence 0.38 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 1.00 Pain Relevance 0.03
In the present study, a higher incidence of S100B elevation was found which probably relates to a higher severity of illness in the patient population studied.
Positive_regulation (incidence) of Gene_expression (elevation) of S100B
19) Confidence 0.38 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 1.03 Pain Relevance 0
We have previously demonstrated that levels of the highly brain-specific protein S100B were increased in low consciousness SAE, suggesting a possible use for this protein as a biomarker of SAE [5].
Positive_regulation (increased) of Gene_expression (levels) of S100B in brain associated with encephalopathy
20) Confidence 0.38 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 1.49 Pain Relevance 0.14

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