INT13193

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Context Info
Confidence 0.44
First Reported 1991
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.22
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FPR1) peptidase activity (ELANE) signal transduction (FPR1)
extracellular region (ELANE) plasma membrane (FPR1) cytoplasm (ELANE)
Anatomy Link Frequency
PMN 1
FPR1 (Homo sapiens)
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 98.60 Very High Very High Very High
lidocaine 7 95.88 Very High Very High Very High
local anesthetic 5 95.44 Very High Very High Very High
dexamethasone 1 91.96 High High
diclofenac 1 89.88 High High
cINOD 7 88.56 High High
Inflammation 32 87.76 High High
Potency 1 25.00 Low Low
Kinase C 5 24.16 Low Low
Analgesic 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 41 96.60 Very High Very High Very High
Hypersensitivity 3 80.28 Quite High
Asthma 4 79.72 Quite High
INFLAMMATION 38 77.88 Quite High
Atherosclerosis 2 59.00 Quite High
Disease 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The histamine H1 antagonists mepyramine and ketotifen and the calcium antagonists verapamil, nifedipine and TMB-8 were also ineffective in suppressing FMLP-induced elastase release.
FMLP Positive_regulation (induced) of elastase associated with antagonist
1) Confidence 0.44 Published 1993 Journal Agents Actions Section Abstract Doc Link 8100381 Disease Relevance 0.54 Pain Relevance 0.44
PMN were stimulated by fMet-Leu-Phe (FMLP) or phorbol myristate acetate (PMA) to elicit chemotaxis, extracellular release of beta-glucuronidase (BGL) and superoxide anion (SOA) production.
FMLP Positive_regulation (stimulated) of PMN in PMN
2) Confidence 0.09 Published 1991 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 1663527 Disease Relevance 0 Pain Relevance 0.46
Considering that the synthetic peptide FMLP, mimetic of bacterial chemotaxins, only activates PMN adhesive machinery, this stimulus was selected to evaluate the effect of the compounds tested on PMNs.
FMLP Positive_regulation (activates) of PMN
3) Confidence 0.00 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.68 Pain Relevance 0.03

General Comments

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