INT131931

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 19.24
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT7) nucleolus (KRT7) structural molecule activity (KRT7)
nucleus (KRT7) cytoskeleton organization (KRT7) cytoplasm (KRT7)
Anatomy Link Frequency
smooth muscle 2
colon 2
biliary tract 1
rectum 1
upper 1
KRT7 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 7 86.48 High High
abdominal pain 9 81.16 Quite High
alcohol 2 75.48 Quite High
iatrogenic 2 70.00 Quite High
Bile 4 62.56 Quite High
imagery 21 58.72 Quite High
peripheral neuropathy 1 55.60 Quite High
positron emission tomography 4 45.20 Quite Low
backache 1 39.84 Quite Low
medulla 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 320 99.78 Very High Very High Very High
Adenocarcinoma 184 99.64 Very High Very High Very High
Colon Cancer 76 99.42 Very High Very High Very High
Rhabdomyosarcoma 2 99.32 Very High Very High Very High
Cyst 48 99.00 Very High Very High Very High
Breast Cancer 45 98.50 Very High Very High Very High
Metastasis 78 98.44 Very High Very High Very High
Thyroid Neoplasm 38 97.84 Very High Very High Very High
Malignant Neoplastic Disease 43 97.68 Very High Very High Very High
Ovarian Cancer 46 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry revealed cytoplasmic positivity for cytokeratin 7-19, specific for the biliary tract epithelium.
cytokeratin 7 Binding (positivity) of in biliary tract
1) Confidence 0.36 Published 2005 Journal Acta Dermatovenerol Croat Section Abstract Doc Link 16324426 Disease Relevance 1.01 Pain Relevance 0.07
It was thus concluded that this was adenocarcinomatous change within an enterogenous cyst as there was smooth muscle lining the walls with cytokeratins CK20 and CK7 both positive, suggesting a fore-gut origin.
CK7 Binding (cytokeratins) of in smooth muscle associated with cyst
2) Confidence 0.36 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2092434 Disease Relevance 0.76 Pain Relevance 0
In such cases, immunohistochemical staining for cytokeratins 7 (CK7) and 20 (CK20) is useful for differentiating primary thyroid cancers from metastatic adenocarcinomas of the colon and rectum.
CK7 Binding (staining) of in rectum associated with thyroid neoplasm and colon cancer
3) Confidence 0.33 Published 2008 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702935 Disease Relevance 1.73 Pain Relevance 0.07
This is shown here for a skin metastasis (on the head) of a poorly differentiated adenocarcinoma: the tumor cells are negative for K7 (c) but positive for K20 (d, left portion of the figure), even including a tumor cell cluster that has invaded a lymphatic capillary (d, right upper corner).
K7 Binding (negative) of in upper associated with adenocarcinoma, cancer and metastasis
4) Confidence 0.15 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.50 Pain Relevance 0
For example, a K7?
K7 Binding (example) of
5) Confidence 0.15 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.54 Pain Relevance 0
Immunohistochemical analysis performed on paraffin-embedded tissue sections was negative for pan-cytokeratin 7 and 20, epithelial membrane antigen (EMA), as well as a smooth muscle actin, desmin, CD34 and CD68.
pan-cytokeratin 7 Binding (actin) of in smooth muscle
6) Confidence 0.14 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2843711 Disease Relevance 0.99 Pain Relevance 0
In such cases, immunohistochemical staining for cytokeratins 7 (CK7) and 20 (CK20) is useful for differentiating primary thyroid cancers from metastatic adenocarcinomas of the colon and rectum.
CK7 Binding (staining) of in colon associated with thyroid neoplasm and colon cancer
7) Confidence 0.11 Published 2008 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702935 Disease Relevance 1.73 Pain Relevance 0.07
Immunohistochemistry showed that the adenocarcinoma cells were diffusely positive for cytokeratin 20 (CK20) and caudal-type homeobox transcription factor-2 (CDX2) but negative for CK7, confirming the colonic phenotype.
CK7 Binding (negative) of associated with adenocarcinoma
8) Confidence 0.06 Published 2008 Journal Pathol. Int. Section Abstract Doc Link 19067855 Disease Relevance 1.37 Pain Relevance 0.08
Colon adenocarcinoma stains positive for CK20 and typically negative for CK7, CA125, TTF1 and ER.
CK7 Binding (negative) of in Colon associated with colon cancer
9) Confidence 0.05 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204026 Disease Relevance 1.37 Pain Relevance 0.06
Both malignancies stain positive for CK7, ER, Mesothelin and CA125.
CK7 Binding (stain) of
10) Confidence 0.05 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204026 Disease Relevance 2.36 Pain Relevance 0
Possibility of an epithelioid rhabdomyosarcoma was discarded considering strong immunoreactvity for CK, CK7 and EMA along with Myo D-1 negativity.
CK7 Binding (immunoreactvity) of associated with rhabdomyosarcoma
11) Confidence 0.05 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1820783 Disease Relevance 1.98 Pain Relevance 0
This result differed from the profile of CK7/CK20 in CRC and was compatible with the profile of CK7/CK20 in SBA reported previously [14].
CK7 Binding (profile) of associated with adenocarcinoma and colon cancer
12) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2917439 Disease Relevance 1.63 Pain Relevance 0.11
Immuno-histochemistry indicated a primary breast tumour as the cells were strongly positive for ER, positive for CK19 and EMA and negative for TTF1, CK20, WT1, CK7, Ca19.9 and Ca125.
CK7 Binding (negative) of associated with breast cancer
13) Confidence 0.03 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2694193 Disease Relevance 1.14 Pain Relevance 0.03

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