INT131944

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 6.58
Pain Relevance 5.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67)
intracellular (Mki67) molecular_function (Mki67) cellular_component (Mki67)
Anatomy Link Frequency
dentate gyrus 3
Liver 2
retina 1
Ki67 1
Brains 1
Mki67 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 525 99.78 Very High Very High Very High
amygdala 472 99.00 Very High Very High Very High
gABA 84 91.80 High High
Paracetamol 12 87.00 High High
Serotonin 22 85.04 High High
depression 181 84.84 Quite High
Hippocampus 77 75.88 Quite High
GABA receptor 14 73.68 Quite High
cva 10 73.20 Quite High
Analgesic 2 69.28 Quite High
Disease Link Frequency Relevance Heat
Cancer 92 99.68 Very High Very High Very High
Sprains And Strains 131 99.48 Very High Very High Very High
Injury 35 97.52 Very High Very High Very High
Anxiety Disorder 375 96.78 Very High Very High Very High
Hyperplasia 15 96.64 Very High Very High Very High
Breast Cancer 26 95.52 Very High Very High Very High
Necrosis 4 91.84 High High
Carcinoma 54 91.20 High High
Apoptosis 58 87.76 High High
Neurodegenerative Disease 304 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proliferation of progenitor cells in the dentate gyrus was measured using BrdU or Ki-67.
Gene_expression (using) of Ki-67 in dentate gyrus
1) Confidence 0.53 Published 2006 Journal Biol. Psychiatry Section Body Doc Link 16325782 Disease Relevance 0.09 Pain Relevance 0
Liver regeneration lasted from 24-192 h according to the results from thymidine kinase activity and Ki-67 expression.
Gene_expression (expression) of Ki-67 in Liver
2) Confidence 0.30 Published 2007 Journal Arch. Toxicol. Section Abstract Doc Link 17431590 Disease Relevance 0.30 Pain Relevance 0.30
As Ki 67 antigen is expressed during the whole cell cycle, it is uncertain whether the moderately stained cells are in the process of mitosis, or the antigen is still expressed in the cell after mitosis.
Gene_expression (expressed) of Ki 67
3) Confidence 0.24 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.08 Pain Relevance 0
In addition both Ki 67 and PCNA expression were significantly increased in EPO compared to GM-CSF treated animals in all post-operative days (p < 0.01).
Gene_expression (expression) of Ki 67
4) Confidence 0.21 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.23 Pain Relevance 0.04
This effect is noted even before any "triggering" for regeneration took place, as rats pre-treated with rhEPO showed increased expression of both Ki 67 and PCNA before hepatectomy was performed.
Gene_expression (expression) of Ki 67
5) Confidence 0.21 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.08 Pain Relevance 0
In our study we chose to evaluate the expression of two proliferation markers -PCNA and Ki 67-, as these have been shown to peak at different timepoints of the cell cycle, and their expression could vary depending on the stage of cellular duplication.
Gene_expression (expression) of Ki 67
6) Confidence 0.21 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.06 Pain Relevance 0.03
Liver injury and regeneration were assessed with hematoxylin-eosin specimens, morphometric analysis, hepatic thymidine kinase assay and Ki-67 expression.
Gene_expression (expression) of Ki-67 in Liver associated with injury
7) Confidence 0.20 Published 2007 Journal Arch. Toxicol. Section Abstract Doc Link 17431590 Disease Relevance 0.24 Pain Relevance 0.45
Ki-67 is expressed in endometrium in all phases of the cell cycle except G0 [37].
Neg (except) Gene_expression (expressed) of Ki-67 in endometrium
8) Confidence 0.17 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.05 Pain Relevance 0
EPO pretreatment increased Ki 67 and PCNA expression preoperatively (p < 0.01).
Gene_expression (expression) of Ki 67
9) Confidence 0.16 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0 Pain Relevance 0
Preoperatively only PCNA was over-expressed, and not Ki 67.
Neg (not) Gene_expression (-) of Ki 67
10) Confidence 0.16 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.10 Pain Relevance 0
On postoperative day 1 all rats had increased Ki 67 and PCNA expression (p < 0.05).


Gene_expression (expression) of Ki 67
11) Confidence 0.16 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0 Pain Relevance 0
Preoperatively only PCNA was over-expressed, and not Ki 67.
Neg (not) Gene_expression (expressed) of Ki 67
12) Confidence 0.16 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.10 Pain Relevance 0
GM-CSF pretreatment as well as the combination of EPO and GM-CSF increased PCNA (p < 0.01), but not Ki 67 expression (p < 0.01).


Gene_expression (expression) of Ki 67
13) Confidence 0.16 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0 Pain Relevance 0
Immunohistochemically stained sections were counter-stained using either hematoxylin (CD68) or DAPI (Ki-67 and DCX), as appropriate.
Gene_expression (using) of Ki-67
14) Confidence 0.15 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2825515 Disease Relevance 0.09 Pain Relevance 0.10
Ki-67 is a nuclear marker of cell proliferation and detectable in cells at all phases of the cell cycles except G0 (Gerdes et al., 1983).
Gene_expression (detectable) of Ki-67
15) Confidence 0.14 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2819973 Disease Relevance 0.40 Pain Relevance 0
Negative controls where the primary antibody was replaced by IgG were negative for both PCNA (Fig. 3F) and Ki-67 (Fig. 3L).
Neg (negative) Gene_expression (negative) of Ki-67
16) Confidence 0.13 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
Similar to our findings, proliferation as measured by Ki-67 expression was not modulated by celecoxib in either ER-positive or ER-negative xenografts.
Gene_expression (expression) of Ki-67
17) Confidence 0.11 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374974 Disease Relevance 1.48 Pain Relevance 0
There were again strain differences in the basal expression of Ki67 in the dentate gyrus (SD>LH: two-way ANOVA: F(1,16)=79.6, P<0.001).
Gene_expression (expression) of Ki67 in dentate gyrus associated with sprains and strains
18) Confidence 0.07 Published 2008 Journal Neuroscience Section Body Doc Link PMC2650100 Disease Relevance 0.79 Pain Relevance 0.53
An additional feature of such labeling was that Ki67-positive RPE cells were also present beyond the immediate lesion area, being present across the entire retina.
Gene_expression (present) of Ki67 in retina
19) Confidence 0.07 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2847682 Disease Relevance 0 Pain Relevance 0
The increased expression of nuclear antigen protein, Ki-67 is an indication of proliferation since it is not expressed in resting cells.
Gene_expression (expression) of Ki-67
20) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994757 Disease Relevance 0 Pain Relevance 0.35

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