INT131969

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 2006
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.57
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grik1) plasma membrane (Grik1)
Anatomy Link Frequency
neurons 2
interneurons 1
Grik1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 48 99.96 Very High Very High Very High
Glutamate 15 99.64 Very High Very High Very High
Glutamate receptor 8 99.56 Very High Very High Very High
substantia gelatinosa 171 99.04 Very High Very High Very High
amygdala 243 99.00 Very High Very High Very High
Pyramidal cell 50 98.56 Very High Very High Very High
Enkephalin 2 97.88 Very High Very High Very High
cocaine 7 97.04 Very High Very High Very High
Action potential 21 96.12 Very High Very High Very High
gABA 106 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 31 97.44 Very High Very High Very High
Nociception 29 65.12 Quite High
Cocaine Dependence 1 50.24 Quite High
Anxiety Disorder 103 50.00 Quite Low
Pain 16 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 5 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low
Epilepsy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on our previous work [25,26], we studied the modulation of GluR5 on inhibitory synaptic transmission in the SG region of slices.
Regulation (modulation) of GluR5 associated with substantia gelatinosa
1) Confidence 0.61 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.45
Furthermore, we showed that this inhibition is under the tonic regulation of GluR5-containing KA receptors on BLA interneurons.
Regulation (regulation) of GluR5 in interneurons associated with amygdala
2) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.55
To investigate whether presynaptic GluR5 KARs are activated by endogenous glutamate, we examined the effect of bath application of GluR5 antagonist, LY293558, on sIPSCs in spinal SG neurons.
Spec (examined) Regulation (effect) of GluR5 in neurons associated with substantia gelatinosa, glutamate and antagonist
3) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.67
Our result showed that GluR5 is selectively acting on inhibitory but not excitatory synaptic transmission in the BLA.
Neg (not) Regulation (acting) of GluR5 associated with amygdala
4) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0 Pain Relevance 0.59
When expressed as "fold-change in expression" the SAGE results demonstrate a down regulation of Grik1, Dock4 and Crip2 expression between P0 WT and P0 Trka-/- DRG of about 18, 6 and 3 fold respectively, while QRT-PCR provided an expression ratio between P0 WT and P0 Trka-/- DRG of 17, 4 and 4 fold respectively.


Regulation (regulation) of Grik1
5) Confidence 0.24 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.13 Pain Relevance 0.16
Mechanism for GluR5 modulation of inhibitory transmission in SG neurons
Regulation (modulation) of GluR5 in neurons associated with substantia gelatinosa
6) Confidence 0.24 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.55
In contrast, mutant mice showed altered response in mRNA levels of N-methyl-D-aspartate, GLUR5 and GLUR6 glutamate receptor subunits as well as of enkephalin following cocaine administration.
Regulation (response) of GLUR5 associated with glutamate receptor, enkephalin and cocaine
7) Confidence 0.20 Published 2006 Journal Neuroscience Section Abstract Doc Link 16326019 Disease Relevance 0.45 Pain Relevance 0.72

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox