INT131973

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.35
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
cerebral cortex 3
hypothalamus 2
striatum 1
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 2 100.00 Very High Very High Very High
depression 169 99.76 Very High Very High Very High
fluoxetine 60 99.12 Very High Very High Very High
Hippocampus 46 98.80 Very High Very High Very High
Thalamus 6 97.44 Very High Very High Very High
withdrawal 4 96.52 Very High Very High Very High
agonist 26 95.92 Very High Very High Very High
butorphanol 5 95.88 Very High Very High Very High
addiction 3 95.40 Very High Very High Very High
antidepressant 228 93.60 High High
Disease Link Frequency Relevance Heat
Depression 183 99.76 Very High Very High Very High
Targeted Disruption 54 50.00 Quite Low
Aids-related Complex 6 14.96 Low Low
Stress 20 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 14 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 9 5.00 Very Low Very Low Very Low
Cognitive Disorder 7 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low
Hypothermia 6 5.00 Very Low Very Low Very Low
Schizophrenia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that increases in expression of mRNA for the GluR-A receptor and in the binding of AMPA to its receptor may play an important role during withdrawal from butorphanol dependence.
Positive_regulation (increases) of Transcription (expression) of GluR-A associated with addiction, butorphanol and withdrawal
1) Confidence 0.49 Published 2005 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 16326431 Disease Relevance 0 Pain Relevance 0.93
The expressions of phospho-Ser845-GluR1 and c-fos mRNA (in striatum and cerebral cortex) are enhanced by administration of fluoxetine or 2-ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT), a 5-HT6 receptor agonist.
Positive_regulation (enhanced) of Transcription (expressions) of GluR1 in cerebral cortex associated with agonist, cerebral cortex and fluoxetine
2) Confidence 0.45 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.17 Pain Relevance 0.84
In the hypothalamus, the mRNA levels of GluR1, GluR3, mGluR1, mGluR3 and NR1 were significantly increased also after the administration of the highest MDMA dose, Figure 2C.
Positive_regulation (increased) of Transcription (levels) of GluR1 in hypothalamus
3) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0
The expressions of phospho-Ser845-GluR1 and c-fos mRNA (in striatum and cerebral cortex) are enhanced by administration of fluoxetine or 2-ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT), a 5-HT6 receptor agonist.
Positive_regulation (enhanced) of in striatum Transcription (expressions) of GluR1 in cerebral cortex associated with agonist, cerebral cortex and fluoxetine
4) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.17 Pain Relevance 0.84

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox