INT131977

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.90
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
signal transducer activity (Avp)
Anatomy Link Frequency
pituitary 4
neurohypophysis 2
Avp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 52 99.66 Very High Very High Very High
depression 32 98.40 Very High Very High Very High
ketamine 3 96.76 Very High Very High Very High
antagonist 51 88.20 High High
Inflammation 12 75.76 Quite High
Kinase C 48 74.20 Quite High
Potency 6 61.76 Quite High
Hippocampus 20 61.48 Quite High
qutenza 1 57.44 Quite High
antidepressant 3 42.96 Quite Low
Disease Link Frequency Relevance Heat
Hypoglycemia 17 98.80 Very High Very High Very High
Depression 38 98.40 Very High Very High Very High
Anxiety Disorder 40 96.52 Very High Very High Very High
Stress 352 96.16 Very High Very High Very High
Hyponatremia 20 94.92 High High
Volume Depletion And Dehydration 8 94.40 High High
Viral Meningitis 4 94.08 High High
Aggression 55 93.96 High High
Meningitis 4 93.44 High High
Targeted Disruption 221 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased Avp secretion and enhanced pituitary responsiveness to Avp have been reported in some subtypes of depression (e.g. melancholic depression)(see, Dinan and Scott 2005 for a review).
Positive_regulation (Increased) of Localization (secretion) of Avp in pituitary associated with depression
1) Confidence 0.55 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.30 Pain Relevance 0.26
Body fluid homeostasis requires the release of arginine-vasopressin (AVP, an antidiuretic hormone) from the neurohypophysis.
Positive_regulation (requires) of Localization (release) of arginine-vasopressin in neurohypophysis
2) Confidence 0.40 Published 2006 Journal Nat. Neurosci. Section Abstract Doc Link 16327782 Disease Relevance 0 Pain Relevance 0.06
Increased Avp secretion and enhanced pituitary responsiveness to Avp have been reported in some subtypes of depression (e.g. melancholic depression)(see, Dinan and Scott 2005 for a review).
Positive_regulation (Increased) of Localization (secretion) of Avp in pituitary associated with depression
3) Confidence 0.40 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.32 Pain Relevance 0.26
Moreover, studies of some specific acute stressors indicate that Avp may be preferentially released in favour of Crh (e.g. insulin-induced hypoglycaemia (IIH) in rats (Plotsky et al. 1985), ketamine anaesthesia and IIH in sheep (Engler et al. 1989)).
Positive_regulation (favour) of Localization (released) of Avp associated with hypoglycemia and ketamine
4) Confidence 0.40 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.80 Pain Relevance 0.08
Among these gene profiling lists, novel factors may be discovered, ones which stimulate the synthesis or secretion of vasopressin.
Positive_regulation (stimulate) of Localization (secretion) of vasopressin
5) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.18 Pain Relevance 0
, IL-6 and other cytokines can promote the induction of the transcription and/or secretion of CRH/vasopressin in vivo.
Positive_regulation (induction) of Localization (secretion) of vasopressin associated with cytokine
6) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.30 Pain Relevance 0.38
In the dissociated fetal hypothalamic cell culture derived from the Fisher (F344/N) rat, 24h exposure of IL-6 stimulates vasopressin release (Wei et al. 2002).
Positive_regulation (stimulates) of Localization (release) of vasopressin
7) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.51 Pain Relevance 0.14
, and lipopolysaccharide also increase the vasopressin secretion in a dose-dependent manner.
Positive_regulation (increase) of Localization (secretion) of vasopressin
8) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.49 Pain Relevance 0.13

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