INT131977

Context Info Confidence 0.55 First Reported 2006 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 8 Disease Relevance 4.90 Pain Relevance 1.31

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp) signal transducer activity (Avp)

Anatomy Link Frequency pituitary 4 neurohypophysis 2 Avp (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 52 99.66 depression 32 98.40 ketamine 3 96.76 antagonist 51 88.20 Inflammation 12 75.76 Kinase C 48 74.20 Potency 6 61.76 Hippocampus 20 61.48 qutenza 1 57.44 antidepressant 3 42.96

Disease Link Frequency Relevance Heat Hypoglycemia 17 98.80 Depression 38 98.40 Anxiety Disorder 40 96.52 Stress 352 96.16 Hyponatremia 20 94.92 Volume Depletion And Dehydration 8 94.40 Viral Meningitis 4 94.08 Aggression 55 93.96 Meningitis 4 93.44 Targeted Disruption 221 86.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increased Avp secretion and enhanced pituitary responsiveness to Avp have been reported in some subtypes of depression (e.g. melancholic depression)(see, Dinan and Scott 2005 for a review).

Positive_regulation (Increased) of Localization (secretion) of Avp in pituitary associated with depression

1) Confidence 0.55 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.30 Pain Relevance 0.26

Body fluid homeostasis requires the release of arginine-vasopressin (AVP, an antidiuretic hormone) from the neurohypophysis.

Positive_regulation (requires) of Localization (release) of arginine-vasopressin in neurohypophysis

2) Confidence 0.40 Published 2006 Journal Nat. Neurosci. Section Abstract Doc Link 16327782 Disease Relevance 0 Pain Relevance 0.06

Increased Avp secretion and enhanced pituitary responsiveness to Avp have been reported in some subtypes of depression (e.g. melancholic depression)(see, Dinan and Scott 2005 for a review).

Positive_regulation (Increased) of Localization (secretion) of Avp in pituitary associated with depression

3) Confidence 0.40 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.32 Pain Relevance 0.26

Moreover, studies of some specific acute stressors indicate that Avp may be preferentially released in favour of Crh (e.g. insulin-induced hypoglycaemia (IIH) in rats (Plotsky et al. 1985), ketamine anaesthesia and IIH in sheep (Engler et al. 1989)).

Positive_regulation (favour) of Localization (released) of Avp associated with hypoglycemia and ketamine

4) Confidence 0.40 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.80 Pain Relevance 0.08

Among these gene profiling lists, novel factors may be discovered, ones which stimulate the synthesis or secretion of vasopressin.

Positive_regulation (stimulate) of Localization (secretion) of vasopressin

5) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.18 Pain Relevance 0

, IL-6 and other cytokines can promote the induction of the transcription and/or secretion of CRH/vasopressin in vivo.

Positive_regulation (induction) of Localization (secretion) of vasopressin associated with cytokine

6) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.30 Pain Relevance 0.38

In the dissociated fetal hypothalamic cell culture derived from the Fisher (F344/N) rat, 24h exposure of IL-6 stimulates vasopressin release (Wei et al. 2002).

Positive_regulation (stimulates) of Localization (release) of vasopressin

7) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.51 Pain Relevance 0.14

, and lipopolysaccharide also increase the vasopressin secretion in a dose-dependent manner.

Positive_regulation (increase) of Localization (secretion) of vasopressin

8) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.49 Pain Relevance 0.13

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