INT131978

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 4.67
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpc1) plasma membrane (Trpc1) protein complex (Trpc1)
transmembrane transport (Trpc1) cytoplasm (Trpc1)
Anatomy Link Frequency
neurons 3
sensory neurons 1
retina 1
aorta 1
brain 1
Trpc1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 30 99.50 Very High Very High Very High
Pain 14 98.92 Very High Very High Very High
TRP channel 121 94.60 High High
nociceptor 16 91.96 High High
ASIC 3 87.92 High High
Mechanosensation 3 87.36 High High
Kinase C 8 82.72 Quite High
Adelta 1 75.68 Quite High
agonist 4 75.00 Quite High
unmyelinated 2 70.24 Quite High
Disease Link Frequency Relevance Heat
Cancer 159 100.00 Very High Very High Very High
Nociception 23 99.92 Very High Very High Very High
Glioblastoma 26 99.16 Very High Very High Very High
Pain 11 98.92 Very High Very High Very High
Obesity 10 97.44 Very High Very High Very High
Ganglion Cysts 30 96.92 Very High Very High Very High
Stress Incontinence 3 96.16 Very High Very High Very High
Disease 6 94.28 High High
Targeted Disruption 17 92.88 High High
Recurrence 4 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We first examined the expression of Trpc1-7 by RT-PCR analyses using total RNA preparations from dissected vestibular ganglion tissue of young adult CF-1 male mice (4-5 weeks old).
Spec (examined) Gene_expression (expression) of Trpc1 in vestibular ganglion associated with ganglion cysts
1) Confidence 0.71 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0.10 Pain Relevance 0
As shown in Fig. 8A-B, Trpc1, 2s, 3, 4, and 7 are expressed in both vestibular tissue and E15 brain/retina.
Gene_expression (expressed) of Trpc1 in brain
2) Confidence 0.71 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0.09 Pain Relevance 0
Oral capsaicin significantly increases transient receptor potential vanilloid type-1 (TRPV1) channel expression as well as TRPV1 messenger ribonucleic acid (mRNA) in visceral adipose tissue.
Gene_expression (expression) of transient receptor potential vanilloid type-1 in adipose tissue associated with qutenza and obesity
3) Confidence 0.63 Published 2008 Journal Life Sci. Section Abstract Doc Link 18541272 Disease Relevance 0.76 Pain Relevance 1.19
Further, we did not observe the strong expression of TRPC1 shown by Garcia and Schilling [11].
Gene_expression (expression) of TRPC1
4) Confidence 0.61 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.03
This study, using continuous infusion cystometry with acetic acid (AA; pH 3.0), was conducted to examine whether the transient receptor potential vanilloid type 1 (TRPV1) channels expressed in the mouse LUT are involved in the sex difference in functional responses of the bladder and urethra to irritation.
Gene_expression (expressed) of transient receptor potential vanilloid type 1 in LUT associated with stress incontinence
5) Confidence 0.52 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 20237234 Disease Relevance 0.16 Pain Relevance 0
Here we show that SON neurons express an N-terminal splice variant of the transient receptor potential vanilloid type-1 (Trpv1), also known as the capsaicin receptor, but not full-length Trpv1.
Neg (not) Gene_expression (express) of transient receptor potential vanilloid type-1 in neurons associated with qutenza
6) Confidence 0.49 Published 2006 Journal Nat. Neurosci. Section Abstract Doc Link 16327782 Disease Relevance 0.09 Pain Relevance 0.10
Signals of TRPC1, C3, C4, C5 and C6 have been reported in mouse and rat aorta, while TRPC2 and C7 transcripts were not observed [7].
Gene_expression (Signals) of TRPC1 in aorta
7) Confidence 0.47 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.09 Pain Relevance 0.08
TRPC1, 2, 3, 4 and 6 are present on endothelial cells, activation of which increases intracellular Ca2+ [35].
Gene_expression (present) of TRPC1 in endothelial cells
8) Confidence 0.34 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.43 Pain Relevance 0.27
TRPP2 did not alter the whole cell currents mediated by expression of TRPC1 (unpublished data), which indicates that physical interaction with TRPP2 alone does not suffice to alter the functional properties of another TRP channel, at least under the experimental conditions used here.


Gene_expression (expression) of TRPC1 associated with trp channel
9) Confidence 0.28 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.13 Pain Relevance 0.09
As shown in Fig. 8A-B, Trpc1, 2s, 3, 4, and 7 are expressed in both vestibular tissue and E15 brain/retina.
Gene_expression (expressed) of Trpc1 in retina
10) Confidence 0.24 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0.09 Pain Relevance 0
In the OE, TRPC1 and 6, TRPM3, 4, 5, 6, and 7, TRPV2 and 6, and TRPA1 have been shown to be expressed by RT-PCR [4].
Gene_expression (expressed) of TRPC1
11) Confidence 0.17 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.09 Pain Relevance 0.16
GBMs over express tumor antigens such as MAGE, Her2/neu, Tyrosinase, Trp-1, Trp-2, gp100, IL13R?
Gene_expression (express) of Trp-1 associated with cancer
12) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 2.15 Pain Relevance 0
Here we show that transient receptor potential ankyrin 1 (TRPA1), expressed by sensory neurons in the pain pathway, is a receptor for H(2)O(2).
Gene_expression (expressed) of transient receptor in sensory neurons associated with pain
13) Confidence 0.11 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18364033 Disease Relevance 0.29 Pain Relevance 0.35
The transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1), which are expressed in the nociceptive neurons, induce a sensation of heat on activation by some pungent ingredients in food.
Gene_expression (expressed) of transient receptor in neurons associated with nociception
14) Confidence 0.04 Published 2009 Journal Life Sci. Section Abstract Doc Link 19409911 Disease Relevance 0.10 Pain Relevance 0.04
The transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1), which are expressed in the nociceptive neurons, induce a sensation of heat on activation by some pungent ingredients in food.
Gene_expression (expressed) of transient receptor in neurons associated with nociception
15) Confidence 0.03 Published 2009 Journal Life Sci. Section Abstract Doc Link 19409911 Disease Relevance 0.10 Pain Relevance 0.04
Intracellular Ca(2+) dependent pathways to HHS varied with the pattern of TRP protein expression.
Gene_expression (expression) of TRP protein
16) Confidence 0.01 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17287441 Disease Relevance 0 Pain Relevance 0.85

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