INT13199

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Context Info
Confidence 0.71
First Reported 1991
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 2.11

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Golgi apparatus (LRBA) endoplasmic reticulum (LRBA) plasma membrane (LRBA)
cytoplasmic membrane-bounded vesicle (LRBA) molecular_function (LRBA) cellular_component (LRBA)
Anatomy Link Frequency
PMN 1
LRBA (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 21 98.64 Very High Very High Very High
local anesthetic 15 90.90 High High
Potency 3 54.32 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PMN were stimulated by fMet-Leu-Phe (FMLP) or phorbol myristate acetate (PMA) to elicit chemotaxis, extracellular release of beta-glucuronidase (BGL) and superoxide anion (SOA) production.
Localization (release) of BGL in PMN
1) Confidence 0.71 Published 1991 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 1663527 Disease Relevance 0 Pain Relevance 0.53
The 50% inhibitory concentrations (IC50 in molarity) of the four local anesthetics for chemotaxis were as follows: tetracaine = 4.1 x 10(-4), lidocaine = 3.2 x 10(-3), prilocaine = 3.6 x 10(-3), procaine = 4.9 x 10(-3), those for SOA production induced by FMLP were: tetracaine = 3.1 x 10(-4), lidocaine = 5.9 x 10(-3), prilocaine = 1.9 x 10(-2), procaine = 1.2 x 10(-2), those for SOA production induced by PMA were: tetracaine = 1.1 x 10(-3), lidocaine = 1.2 x 10(-2), prilocaine = 1.5 x 10(-2), procaine = 2.5 x 10(-2), and those for release of BGL were: tetracaine = 1.6 x 10(-3), lidocaine = 5.3 x 10(-3), prilocaine = 2.8 x 10(-2), procaine = 1.2 x 10(-1).
Localization (release) of BGL associated with lidocaine and local anesthetic
2) Confidence 0.54 Published 1991 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 1663527 Disease Relevance 0 Pain Relevance 0.96
The four agents inhibited chemotaxis efficiently and in a concentration-dependent manner but had only weak effects on the release of BGL.
Localization (release) of BGL
3) Confidence 0.54 Published 1991 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 1663527 Disease Relevance 0 Pain Relevance 0.62

General Comments

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