INT132001

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.64
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nerve 1
basal lamina 1
Col4a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 6 72.00 Quite High
Neuropathic pain 1 51.68 Quite High
antagonist 83 28.60 Quite Low
fibrosis 22 13.84 Low Low
Nerve growth factor 56 5.00 Very Low Very Low Very Low
Inflammation 54 5.00 Very Low Very Low Very Low
agonist 47 5.00 Very Low Very Low Very Low
cytokine 44 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 34 5.00 Very Low Very Low Very Low
substance P 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 14 98.72 Very High Very High Very High
Immunization 17 86.48 High High
Hypertrophy 12 78.44 Quite High
Nervous System Injury 1 75.00 Quite High
Injury 5 61.84 Quite High
Coronary Heart Disease 20 58.92 Quite High
Cancer 44 50.36 Quite High
Autoimmune Disease 2 50.00 Quite Low
Body Weight 6 40.68 Quite Low
Pituitary Cancer 22 20.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunofluorescence for laminin-1 exactly coincided with binding of Concanavalin-A as well as immunostaining for type IV collagen in both naive DRG and DRG affected by nerve ligature.
type IV collagen Binding (binding) of in nerve
1) Confidence 0.13 Published 2006 Journal Histochem. Cell Biol. Section Abstract Doc Link 16333605 Disease Relevance 0.14 Pain Relevance 0.05
Further, the collagen type I maintaining tissue structure and collagen type IV, a component of basal lamina that allows interaction with integrins and favors cell adhesion, were increased expressed.
collagen type IV Binding (interaction) of in basal lamina associated with adhesions
2) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.40 Pain Relevance 0.04
Collagen type IV confers structural stability, whereas HSPGs cross-link the collagen type IV and laminins.
collagen type IV Binding (cross) of
3) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.05 Pain Relevance 0
Collagen type IV confers structural stability, whereas HSPGs cross-link the collagen type IV and laminins.
collagen type IV Binding (link) of
4) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.05 Pain Relevance 0

General Comments

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