INT132027

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 2.24
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntn1) proteinaceous extracellular matrix (Ntn1) cytoplasm (Ntn1)
Anatomy Link Frequency
macrophages 1
sciatic nerves 1
HGF 1
Ntn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 18 100.00 Very High Very High Very High
Neuritis 16 99.68 Very High Very High Very High
Sciatic nerve 12 99.54 Very High Very High Very High
Peripheral nervous system 2 92.36 High High
Inflammatory response 6 57.60 Quite High
Inflammation 8 53.84 Quite High
anesthesia 6 38.64 Quite Low
fibrosis 6 20.00 Low Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Neuronal nitric oxide synthase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 16 99.68 Very High Very High Very High
Immunization 2 97.56 Very High Very High Very High
Injury 16 93.52 High High
Myocardial Infarction 36 91.92 High High
Colon Cancer 2 83.36 Quite High
Death 6 80.72 Quite High
Stress 6 79.12 Quite High
INFLAMMATION 14 57.60 Quite High
Apoptosis 6 46.40 Quite Low
Infarction 24 22.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the sciatic nerves of EAN-affected rats, netrin-1 immunoreactivity was increased mainly in the cell membrane and extracellular matrix of OX42-positive macrophages and S100-positive Schwann cells at the peak and recovery phases of EAN.
Positive_regulation (increased) of netrin-1 in macrophages associated with sciatic nerve and neuritis
1) Confidence 0.50 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16337279 Disease Relevance 0.82 Pain Relevance 0.90
Western blot analysis revealed a significant increase in the level of netrin-1 protein in the sciatic nerves of rats on days 11 to 24 post-immunization (p.i.) compared to controls; netrin-1 expression declined by day 30 p.i.
Positive_regulation (increase) of netrin-1 in sciatic nerves associated with immunization and sciatic nerve
2) Confidence 0.47 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16337279 Disease Relevance 0.64 Pain Relevance 0.66
In conclusion ShhMSCs showed upregulation of several angiogenic cytokines and signaling molecules including Ang-1, VEGF, IGF, HGF, iNOS and netrin-1.
Positive_regulation (upregulation) of netrin-1 in HGF associated with cytokine
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0.05
Significant upregulation of netrin-1 and iNOS was observed in ShhMSCs in PI3K independent but PKC dependent manner.
Positive_regulation (upregulation) of netrin-1
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797399 Disease Relevance 0.09 Pain Relevance 0
We propose that the increased angiogenesis is due to the production of NO with simultaneous upregulation of multiple angio-competent factors including netrin-1.
Positive_regulation (upregulation) of netrin-1
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.07 Pain Relevance 0
Shh-induced upregulation of netrin-1 and iNOS was PKC dependent.
Positive_regulation (upregulation) of netrin-1
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0
These results indicated that PKC was essential for Shh mediated upregulation of both iNOS and netrin-1.


Positive_regulation (upregulation) of netrin-1
7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.45 Pain Relevance 0.03
Real-time PCR showed more than 60-fold increase in netrin-1 mRNA levels (Table S3).
Positive_regulation (increase) of netrin-1 mRNA
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.17 Pain Relevance 0

General Comments

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