INT13203

Context Info Confidence 0.01 First Reported 1991 Last Reported 1991 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 1.18

cytoplasm (Oprd1, Akr1d1) cytosol (Akr1d1) oxidoreductase activity (Akr1d1) plasma membrane (Oprd1) signal transducer activity (Oprd1)

Oprd1 (Rattus norvegicus) Akr1d1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 5 100.00 opioid receptor 2 100.00 dopamine receptor 1 97.32 opiate 4 91.84 Morphine 3 86.36 narcan 1 85.12 antagonist 1 84.72 agonist 2 73.16 Enkephalin 1 71.36 cerebral cortex 1 63.44

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It was shown that the D1 (dopamine) receptor-stimulated activity of adenylate cyclase was inhibited by the mu and delta opioid receptor ligands.

delta opioid receptor Negative_regulation (inhibited) of D1 associated with dopamine and opioid receptor

1) Confidence 0.01 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1663598 Disease Relevance 0 Pain Relevance 1.18

General Comments

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