INT13205

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Context Info
Confidence 0.01
First Reported 1991
Last Reported 2000
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1, Npr1) intracellular (Npr1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Oprd1 (Rattus norvegicus)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 2 100.00 Very High Very High Very High
Dopamine 5 99.12 Very High Very High Very High
dopamine receptor 1 95.08 Very High Very High Very High
opiate 4 91.84 High High
Morphine 3 84.12 Quite High
narcan 1 82.88 Quite High
antagonist 1 82.48 Quite High
agonist 3 70.92 Quite High
Enkephalin 1 69.12 Quite High
cerebral cortex 1 61.20 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was shown that the D1 (dopamine) receptor-stimulated activity of adenylate cyclase was inhibited by the mu and delta opioid receptor ligands.
delta opioid receptor Negative_regulation (inhibited) of cyclase associated with dopamine and opioid receptor
1) Confidence 0.01 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1663598 Disease Relevance 0 Pain Relevance 1.16
Unlike U69593 and U50488H, bremazocine is also an antagonist at mu- and delta-opioid receptors, as well as an agonist at a subtype of delta-opioid receptors inhibiting dopamine D1 receptor-stimulated adenylate cyclase.
delta-opioid Negative_regulation (inhibiting) of cyclase
2) Confidence 0.01 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10867974 Disease Relevance 0 Pain Relevance 0

General Comments

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