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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2006
Negated 2
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.24
Pain Relevance 1.43

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cell differentiation (Nkx2-2) nucleus (Nkx2-2) molecular_function (Nkx2-2)
transcription factor binding (Nkx2-2)
Anatomy Link Frequency
plasma 2
bone marrow 2
Nkx2-2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 5 100.00 Very High Very High Very High
qutenza 9 99.72 Very High Very High Very High
substance P 3 99.20 Very High Very High Very High
Somatostatin 4 97.64 Very High Very High Very High
Neuropeptide 4 94.16 High High
neuropeptide release 2 57.52 Quite High
induced neuropathy 1 54.96 Quite High
c fibre 1 54.08 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 75.00 Quite High
Hematological Disease 1 54.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed that both preprotachykinin (PPT)-I mRNA and the tachykinin neurokinin (NK)-1 mRNA expression in bone marrow cells significantly increased in capsaicin group, whereas the NK-2 mRNA expression was unchanged after capsaicin pretreatment.
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of NK-2 mRNA in bone marrow associated with qutenza
1) Confidence 0.10 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16959413 Disease Relevance 0.05 Pain Relevance 0.75
The cisplatin treatment significantly increased plasma somatostatin immunoreactivity and the expression of SSTR4 receptor detected both on the 11th and 22nd post-treatment days with no change in either CGRP, NK1, and NK2 receptor gene expression or plasma CGRP and substance P levels.
Neg (no) Regulation (change) of Gene_expression (expression) of NK2 in plasma associated with somatostatin, substance p and calcitonin gene-related peptide
2) Confidence 0.05 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.19 Pain Relevance 0.68

General Comments

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