INT132103

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 16.54
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
fibroblasts 10
cartilage 4
brains 4
epithelial cells 4
pericytes 2
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 450 99.64 Very High Very High Very High
Inflammatory stimuli 5 99.54 Very High Very High Very High
agonist 18 97.60 Very High Very High Very High
Inflammation 248 95.28 Very High Very High Very High
rheumatoid arthritis 15 94.40 High High
metalloproteinase 151 91.36 High High
cINOD 18 90.24 High High
dexamethasone 13 87.60 High High
Osteoarthritis 41 85.72 High High
cytokine 61 85.48 High High
Disease Link Frequency Relevance Heat
Stress 679 100.00 Very High Very High Very High
Alzheimer's Dementia 90 100.00 Very High Very High Very High
Amyloid Plaque 76 99.90 Very High Very High Very High
Disease 1196 99.84 Very High Very High Very High
INFLAMMATION 289 99.38 Very High Very High Very High
Infection 79 98.96 Very High Very High Very High
Sprains And Strains 106 98.08 Very High Very High Very High
Apoptosis 349 97.24 Very High Very High Very High
Cancer 314 95.76 Very High Very High Very High
Rheumatoid Arthritis 15 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the link between amyloid deposits and JNK activation, we performed an immunostaining in brains of the AD animal model (Tg2576 mice) and found that phospho-JNK immunoreactivity was localized in the surrounding region of senile plaques, which was positive with A?
Positive_regulation (-) of Gene_expression (activation) of JNK in brains associated with alzheimer's dementia and amyloid plaque
1) Confidence 0.46 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.91 Pain Relevance 0.04
To determine the link between amyloid deposits and JNK activation, we performed an immunostaining in brains of the AD animal model (Tg2576 mice) and found that phospho-JNK immunoreactivity was localized in the surrounding region of senile plaques, which was positive with A?
Positive_regulation (-) of Gene_expression (immunoreactivity) of JNK in brains associated with alzheimer's dementia and amyloid plaque
2) Confidence 0.46 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.88 Pain Relevance 0.04
Western blot analysis revealed that EBC1-Ps had higher JNK phosphorylation levels than EBC1-Vs, and sp600125-treated EBC1-Ps showed similar levels of phosphorylated JNK as in EBC1-Vs (Figure 6B).
Positive_regulation (levels) of Gene_expression (had) of JNK
3) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.05 Pain Relevance 0
By contrast, as shown in Figure 6B, not only the phosphorylated JNK but also the total JNK levels were apparently increased in stable transformants exogenously expressing podoplanin.
Positive_regulation (increased) of Gene_expression (levels) of JNK
4) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.19 Pain Relevance 0.04
By contrast, as shown in Figure 6B, not only the phosphorylated JNK but also the total JNK levels were apparently increased in stable transformants exogenously expressing podoplanin.
Positive_regulation (increased) of Gene_expression (levels) of JNK
5) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.19 Pain Relevance 0.04
Intracellular Ca(2+) triggered the activation of mitogen-activated protein kinase (MAPK) in HMC-1, especially p42 and p44 isoforms of extracellular signal-regulated kinase (ERK) and p38 MAPK, but not c-Jun N-terminal kinase (JNK).
Positive_regulation (activation) of Gene_expression (isoforms) of c-Jun N-terminal kinase
6) Confidence 0.36 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.17 Pain Relevance 0.21
Intracellular Ca(2+) triggered the activation of mitogen-activated protein kinase (MAPK) in HMC-1, especially p42 and p44 isoforms of extracellular signal-regulated kinase (ERK) and p38 MAPK, but not c-Jun N-terminal kinase (JNK).
Positive_regulation (activation) of Gene_expression (isoforms) of JNK
7) Confidence 0.36 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.17 Pain Relevance 0.21
One example is the MAPK kinase JNK, which is found to be activated after Pa-PDT treatment (Figure 5A).
Positive_regulation (activated) of Gene_expression (found) of JNK
8) Confidence 0.31 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.97 Pain Relevance 0
Thus H2O2-induced oxidative stress resulted in early lagging ERK and later enhanced JNK activation in the PS-1 (M146L) AD fibroblasts.
Positive_regulation (enhanced) of Gene_expression (activation) of JNK in fibroblasts associated with stress and disease
9) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.51 Pain Relevance 0
Similarly to ERK, the stress-activated MAPK modules of JNK (Figure 4A–C) and p38 (Figure 5A–C) were both activated by both BK concentrations and showed a diminished response in the PS-1 (M146L) fibroblasts.
Positive_regulation (activated) of Gene_expression (modules) of JNK in fibroblasts associated with stress and bradykinin
10) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.73 Pain Relevance 0.28
Cell lysates collected in 1% SDS were immunoblotted for expression and activation of ERK, JNK and p38 and normalized to the loading control protein tubulin.
Positive_regulation (activation) of Gene_expression (expression) of JNK
11) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.35 Pain Relevance 0.25
Hydrogen peroxide-induced oxidative stress evokes lagging ERK activation and enhanced JNK activation in AD fibroblasts
Positive_regulation (induced) of Gene_expression (activation) of JNK in fibroblasts associated with stress and disease
12) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.31 Pain Relevance 0.43
Similarly to ERK, the stress-activated MAPK modules of JNK (Figure 4A–C) and p38 (Figure 5A–C) were both activated by both BK concentrations and showed a diminished response in the PS-1 (M146L) fibroblasts.
Positive_regulation (activated) of Gene_expression (modules) of JNK in fibroblasts associated with stress and bradykinin
13) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.74 Pain Relevance 0.28
Hydrogen peroxide-induced oxidative stress evokes lagging ERK activation and enhanced JNK activation in AD fibroblasts
Positive_regulation (enhanced) of Gene_expression (activation) of JNK in fibroblasts associated with stress and disease
14) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.29 Pain Relevance 0.40
-induced JNK activation in ASMC, having no effect on p38 MAPK and ERK activation [39].
Positive_regulation (induced) of Gene_expression (activation) of JNK
15) Confidence 0.28 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.46
mediated JNK signalling in response to cellular activation by trypsin suggesting a PAR2 mediated response.
Positive_regulation (response) of Gene_expression (signalling) of JNK
16) Confidence 0.25 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.22 Pain Relevance 0.37
-stimulated levels of p-JNK significantly decreased in the presence of SP (10 ?
Positive_regulation (stimulated) of Gene_expression (levels) of p-JNK
17) Confidence 0.17 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0 Pain Relevance 0
Inhibition of the individual MAP kinase pathways with specific chemical inhibitors either completely abolished or significantly reduced expression levels of cartilage-specific genes in a pattern distinct to each pathway, thus indicating that p38, ERK, and JNK are independently essential for the TGF-?
Neg (independently) Positive_regulation (independently) of Gene_expression (essential) of JNK in cartilage
18) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.23 Pain Relevance 0
Inhibition of the individual MAP kinase pathways with specific chemical inhibitors either completely abolished or significantly reduced expression levels of cartilage-specific genes in a pattern distinct to each pathway, thus indicating that p38, ERK, and JNK are independently essential for the TGF-?
Positive_regulation (for) of Gene_expression (essential) of JNK in cartilage
19) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.23 Pain Relevance 0
In the present study, we further found that melittin and bee venom significantly reduced inflammatory stimuli (LPS and SNP)-induced activation of JNK signal, and the JNK signal specific inhibitor SP600215 suppressed the inhibitory effect of melittin and bee venom on the NF-?
Positive_regulation (activation) of Gene_expression (signal) of JNK associated with inflammatory stimuli
20) Confidence 0.13 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.79 Pain Relevance 0.40

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