INT132104

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD1D) histone binding (CD1D) plasma membrane (CD1D)
cytoplasm (CD1D)
CD1D (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 62 100.00 Very High Very High Very High
cINOD 1 82.40 Quite High
Inflammation 13 80.16 Quite High
dexamethasone 5 79.76 Quite High
chemokine 2 78.36 Quite High
Catecholamine 16 72.96 Quite High
antagonist 10 65.68 Quite High
cocaine 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 18 84.64 Quite High
INFLAMMATION 14 82.00 Quite High
Increased Venous Pressure Under Development 3 76.44 Quite High
Stress 13 75.00 Quite High
Acute-phase Reaction 5 5.00 Very Low Very Low Very Low
Cardiovascular Disease 4 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Heart Disease 2 5.00 Very Low Very Low Very Low
Atherosclerotic Plaque 2 5.00 Very Low Very Low Very Low
Coronary Artery Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracellular Ca(2+) triggered the activation of mitogen-activated protein kinase (MAPK) in HMC-1, especially p42 and p44 isoforms of extracellular signal-regulated kinase (ERK) and p38 MAPK, but not c-Jun N-terminal kinase (JNK).
Positive_regulation (activation) of Gene_expression (isoforms) of HMC-1
1) Confidence 0.03 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.16 Pain Relevance 0.20
significantly induced production of these cytokines in HMC-1, while epinephrine alone did not.
Positive_regulation (induced) of Gene_expression (production) of HMC-1 associated with cytokine
2) Confidence 0.01 Published 2004 Journal BMC Immunol Section Abstract Doc Link PMC521685 Disease Relevance 0.39 Pain Relevance 0.37

General Comments

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