INT132163

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 8.96
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1)
cytoplasm (MUC1)
Anatomy Link Frequency
middle ear 2
tracheal epithelial cells 2
lung 2
mucous cells 2
mesenchymal cells 2
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 478 99.90 Very High Very High Very High
Inflammatory mediators 72 98.44 Very High Very High Very High
cytokine 195 93.76 High High
Opioid 3 91.04 High High
antagonist 4 90.48 High High
mu opioid receptor 2 79.80 Quite High
chemokine 51 74.72 Quite High
Inflammatory response 41 72.28 Quite High
opioid receptor 1 67.64 Quite High
potassium channel 3 64.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 577 99.90 Very High Very High Very High
Stress 7 99.90 Very High Very High Very High
Hypersensitivity 133 99.64 Very High Very High Very High
Otitis Media 402 98.80 Very High Very High Very High
Nicotine Addiction 133 98.24 Very High Very High Very High
Pneumococcal Infection 36 97.60 Very High Very High Very High
Pulmonary Disease 65 97.18 Very High Very High Very High
Reprotox - General 1 2 96.72 Very High Very High Very High
Hyperplasia 20 96.08 Very High Very High Very High
Otitis Media With Effusion 276 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, the concentrations of MUC-1, a progesterone-dependent glycoprotein secreted by the glands, are lower at day LH + 10 in women suffering recurrent spontaneous miscarriage than in fertile controls [55].
Positive_regulation (dependent) of Localization (secreted) of MUC-1 in glands associated with reprotox - general 1
1) Confidence 0.19 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.25 Pain Relevance 0.03
Figure 4 shows a typical DEAE-Sepharose chromatography elution pattern of the mucins prior to and after rebamipide administration, revealing that rebamipide administration increased gastric mucin secretion specifically by augmenting Fr.
Positive_regulation (increased) of Localization (secretion) of mucin
2) Confidence 0.12 Published 2008 Journal Dig Dis Sci Section Body Doc Link PMC2690849 Disease Relevance 0 Pain Relevance 0
The observed decrease in mucin stores in long-term ex-smokers with COPD, and its relation with duration of smoking cessation, can be explained by decreased goblet cell numbers, decreased mucin production, and/or increased mucin secretion.
Positive_regulation (increased) of Localization (secretion) of mucin in goblet cell associated with pulmonary disease and nicotine addiction
3) Confidence 0.12 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.67 Pain Relevance 0.03
In addition, pentagastrin, by lowering the gastric luminal pH, has been reported to function as a strong stimulus for mucin release from the mucous cells [31, 32], and this property also facilitates the recovery of gastric mucus and the correct timing of collections under a pentagastrin-stimulated condition.
Positive_regulation (stimulus) of Localization (release) of mucin in mucous cells
4) Confidence 0.10 Published 2008 Journal Dig Dis Sci Section Body Doc Link PMC2690849 Disease Relevance 0 Pain Relevance 0
Mucin secretion was maximally increased after 8 h of stimulation.
Positive_regulation (increased) of Localization (secretion) of Mucin
5) Confidence 0.04 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16357059 Disease Relevance 0 Pain Relevance 0.38
Lastly, some believe that joint stress may stimulate mucin secretion by the mesenchymal cells detected by electron microscopy in the surrounding tissues.
Spec (may) Positive_regulation (stimulate) of Localization (secretion) of mucin in mesenchymal cells associated with stress
6) Confidence 0.02 Published 2008 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2682407 Disease Relevance 1.34 Pain Relevance 0
was reported to stimulate secretion of mucin by guinea pig tracheal epithelial cells via mechanisms involving activation of NO synthase (NOS) and generation of NO (243).
Positive_regulation (stimulate) of Localization (secretion) of mucin in tracheal epithelial cells
7) Confidence 0.01 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.85 Pain Relevance 0.03
However, more reports demonstrating direct correlation between IL-6 and upregulation of mucin secretion are necessary to show transition to chronicity of OM.


Positive_regulation (upregulation) of Localization (secretion) of mucin associated with otitis media
8) Confidence 0.01 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.84 Pain Relevance 0.21
, interleukin-l, and PAF induction of mucin secretion in the middle ear epithelium.
Positive_regulation (induction) of Localization (secretion) of mucin in middle ear
9) Confidence 0.01 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.69 Pain Relevance 0.51
Allergic inflammation and induced mucin secretion affect neither survival nor whole lung bacterial counts in pneumococcal pneumonia
Positive_regulation (induced) of Localization (secretion) of mucin in lung associated with pneumococcal infection, inflammation and hypersensitivity
10) Confidence 0.01 Published 2009 Journal Respir Res Section Body Doc Link PMC2724420 Disease Relevance 1.45 Pain Relevance 0.25
To stimulate mucin secretion, ovalbumin sensitized mice were exposed to a 5 min ATP aerosol (100 mM) 3 days after ovalbumin aerosol challenge, as we have previously described to achieve maximal degranulation [14,15].


Positive_regulation (stimulate) of Localization (secretion) of mucin
11) Confidence 0.01 Published 2009 Journal Respir Res Section Body Doc Link PMC2724420 Disease Relevance 0.86 Pain Relevance 0.10

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