INT132164

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 8
Disease Relevance 4.15
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Muc1) molecular_function (Muc1) cytoplasm (Muc1)
Anatomy Link Frequency
pancreas 2
Schwann cells 1
Muc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 4 98.76 Very High Very High Very High
mu opioid receptor 2 92.40 High High
opioid receptor 1 80.24 Quite High
Opioid 3 75.84 Quite High
antagonist 1 66.56 Quite High
fibrosis 1 53.44 Quite High
Inflammation 1 52.48 Quite High
Chronic pancreatitis 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Recurrence 4 99.92 Very High Very High Very High
Disease 4 99.48 Very High Very High Very High
Cancer 7 99.42 Very High Very High Very High
Adhesions 16 99.32 Very High Very High Very High
Pancreatic Cancer 18 99.02 Very High Very High Very High
Pain 4 98.76 Very High Very High Very High
Adenoma 1 95.60 Very High Very High Very High
Adenocarcinoma 4 92.40 High High
Cyst 7 86.64 High High
Pancreatitis 4 54.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No changes in the expression of Muc1 and Muc4 mucins were observed.
Gene_expression (expression) of Muc1
1) Confidence 0.71 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0
The expression profiles of trypsinogen, pancreas-specific trypsin inhibitor, cholecystokinin A receptor, cystic fibrosis transmembrane conductance regulator (CFTR), carbonic anhydrase, and Muc1 and Muc4 mucins transcripts were analyzed by RNA slot blot analysis.
Spec (analyzed) Gene_expression (expression) of Muc1 in pancreas
2) Confidence 0.71 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0
Immunohistochemical analysis of pancreatic perineural invasion showed the expression of both MUC1 and MAG.
Gene_expression (expression) of MUC1
3) Confidence 0.66 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974963 Disease Relevance 0.74 Pain Relevance 0.05
Heterotypic adhesion assays between pancreatic cancer cells and Schwann cells revealed that increased expression of MUC1 or MAG enhanced adhesion.
Gene_expression (expression) of MUC1 in Schwann cells associated with pancreatic cancer and adhesions
4) Confidence 0.66 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974963 Disease Relevance 0.90 Pain Relevance 0.06
Results showed that MAG binds pancreatic cells expressing MUC1, that this binding is sialidase-sensitive, and that MAG physically associates with MUC1.
Gene_expression (expressing) of MUC1
5) Confidence 0.66 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974963 Disease Relevance 0.90 Pain Relevance 0.07
MUC1, a type I transmembrane mucin that can affect the adhesive properties of cells, contains a large extracellular tandem repeat domain, which is heavily glycosylated in normal epithelia, but is overexpressed and differentially glycosylated in pancreatic cancer.
Gene_expression (overexpressed) of MUC1 associated with pancreatic cancer
6) Confidence 0.57 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974963 Disease Relevance 0.73 Pain Relevance 0.10
The cells forming the basal/parabasal region expressed p63 (transitional/squamous cell marker, not detected in any normal pancreas or nonsquamous neoplasia) and the surface cells were positive for MUC 1 and MUC 6 (markers present in intercalated duct cells), and negative for GLUT-1 (consistent marker of serous adenomas).
Neg (negative) Gene_expression (positive) of MUC 1 in pancreas associated with adenoma and cancer
7) Confidence 0.09 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 17255775 Disease Relevance 0.88 Pain Relevance 0.05
In rat DHE cells, beta-casomorphin-7 increased the expression of rat mucin (rMuc)2 and rMuc3 but not rMuc1, rMuc4, and rMuc5AC.
Gene_expression (expression) of rMuc1
8) Confidence 0.00 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16357059 Disease Relevance 0 Pain Relevance 0.34

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