INT132177

Context Info Confidence 0.19 First Reported 2005 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.84 Pain Relevance 1.00

extracellular region (CD27)

Anatomy Link Frequency CD86 1 B cell 1 CD27 (Homo sapiens)

Pain Link Frequency Relevance Heat abatacept 6 98.72 chemokine 82 89.04 Inflammation 20 88.72 rheumatoid arthritis 67 87.84 Osteoarthritis 19 82.44 methotrexate 1 66.64 cytokine 5 5.00 cINOD 3 5.00 Shingles 3 5.00 Dermatone 2 5.00

Disease Link Frequency Relevance Heat Infection 43 99.64 INFLAMMATION 21 88.72 Rheumatoid Arthritis 67 87.84 Osteoarthritis 20 82.44 Systemic Lupus Erythematosus 39 81.80 Exanthema 18 79.64 Herpes Zoster 102 75.68 Cancer 3 64.88 Necrosis 3 64.40 Disease Progression 1 55.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Levels of CD27 expression used to define the various B cell subsets were defined by triple staining with CD19, CD20 and CD27 as shown in Fig. 2a.

CD27 Binding (staining) of in B cell

1) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.63 Pain Relevance 0.41

SVV infection induced a robust proliferation of CD27+IgD+ as well as isotype-switched CD27+IgD?

CD27 Binding (proliferation) of associated with infection

2) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2770849 Disease Relevance 0.56 Pain Relevance 0

The fusion protein abatacept is a selective costimulation modulator that avidly binds to the CD80/CD86 ligands on an antigen-presenting cell, resulting in the inability of these ligands to engage the CD28 receptor on the T cell.

CD28 receptor Binding (engage) of in CD86 associated with abatacept

3) Confidence 0.01 Published 2005 Journal J Clin Rheumatol Section Abstract Doc Link 16357751 Disease Relevance 0.65 Pain Relevance 0.59

General Comments

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