INT132177

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.84
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD27)
Anatomy Link Frequency
CD86 1
B cell 1
CD27 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 6 98.72 Very High Very High Very High
chemokine 82 89.04 High High
Inflammation 20 88.72 High High
rheumatoid arthritis 67 87.84 High High
Osteoarthritis 19 82.44 Quite High
methotrexate 1 66.64 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Shingles 3 5.00 Very Low Very Low Very Low
Dermatone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 43 99.64 Very High Very High Very High
INFLAMMATION 21 88.72 High High
Rheumatoid Arthritis 67 87.84 High High
Osteoarthritis 20 82.44 Quite High
Systemic Lupus Erythematosus 39 81.80 Quite High
Exanthema 18 79.64 Quite High
Herpes Zoster 102 75.68 Quite High
Cancer 3 64.88 Quite High
Necrosis 3 64.40 Quite High
Disease Progression 1 55.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of CD27 expression used to define the various B cell subsets were defined by triple staining with CD19, CD20 and CD27 as shown in Fig. 2a.
CD27 Binding (staining) of in B cell
1) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.63 Pain Relevance 0.41
SVV infection induced a robust proliferation of CD27+IgD+ as well as isotype-switched CD27+IgD?
CD27 Binding (proliferation) of associated with infection
2) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2770849 Disease Relevance 0.56 Pain Relevance 0
The fusion protein abatacept is a selective costimulation modulator that avidly binds to the CD80/CD86 ligands on an antigen-presenting cell, resulting in the inability of these ligands to engage the CD28 receptor on the T cell.
CD28 receptor Binding (engage) of in CD86 associated with abatacept
3) Confidence 0.01 Published 2005 Journal J Clin Rheumatol Section Abstract Doc Link 16357751 Disease Relevance 0.65 Pain Relevance 0.59

General Comments

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