INT132186

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.73
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 38 90.16 High High
Inflammation 12 80.88 Quite High
Pain 5 65.52 Quite High
cytokine 4 50.00 Quite Low
Chronic pancreatitis 2 50.00 Quite Low
metalloproteinase 8 48.88 Quite Low
Analgesic 2 41.12 Quite Low
Arthritis 15 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 25 92.00 High High
Hyperplasia 8 90.84 High High
Osteoarthritis 39 90.16 High High
Stress 4 88.48 High High
INFLAMMATION 10 80.88 Quite High
Diabetes Mellitus 22 79.80 Quite High
Disease Progression 1 79.40 Quite High
Neointima 6 77.92 Quite High
Pain 5 65.52 Quite High
Pancreatitis 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effect of alagebrium on neointimal formation may also be mediated by reduction of ECM production.



Negative_regulation (reduction) of Gene_expression (production) of ECM
1) Confidence 0.06 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.63 Pain Relevance 0
IL-1 causes both matrix degradation and downregulation of proteoglycan synthesis [37], but further studies are required to clarify whether FGF8 also downregulates ECM synthesis.
Spec (whether) Negative_regulation (downregulates) of Gene_expression (synthesis) of ECM
2) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.10 Pain Relevance 0.54
CONCLUSIONS: Troglitazone prevented the progression of chronic pancreatitis via inhibition of ECM synthesis and proinflammatory cytokine production mediated by the inhibition of NF-kappaB activity.


Negative_regulation (inhibition) of Gene_expression (synthesis) of ECM
3) Confidence 0.01 Published 2005 Journal Rocz. Akad. Med. Bialymst. Section Body Doc Link 16358954 Disease Relevance 0 Pain Relevance 0

General Comments

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