INT132187

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.12
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
cartilage 3
ECM 2
liver 1
lung 1
articular cartilage 1
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 77 99.30 Very High Very High Very High
Osteoarthritis 168 98.28 Very High Very High Very High
Deafferentation 4 97.60 Very High Very High Very High
Hippocampus 56 95.24 Very High Very High Very High
Inflammation 110 93.68 High High
metalloproteinase 167 93.24 High High
Arthritis 46 91.96 High High
Inflammatory stimuli 2 91.44 High High
cytokine 55 89.84 High High
Potency 4 86.36 High High
Disease Link Frequency Relevance Heat
Alkalosis 2 99.82 Very High Very High Very High
Cirrhosis 84 99.74 Very High Very High Very High
Acidosis 2 99.62 Very High Very High Very High
Fibrosis 44 98.40 Very High Very High Very High
Osteoarthritis 170 98.28 Very High Very High Very High
Synovitis 2 98.12 Very High Very High Very High
Acid Base Imbalance 2 96.88 Very High Very High Very High
Injury 75 96.80 Very High Very High Very High
Lung Injury 9 95.40 Very High Very High Very High
Hypocapnia 5 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that collagen V, an ECM protein that is highly expressed during tissue development and repair, modifies cell morphology and migration on substrates with a tissue-like stiffness, but not on hard substrates (R.G.M.
Gene_expression (expressed) of ECM protein
1) Confidence 0.21 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2687114 Disease Relevance 0 Pain Relevance 0
The inhibitory effect of alagebrium on neointimal formation may also be mediated by reduction of ECM production.



Gene_expression (production) of ECM
2) Confidence 0.08 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.63 Pain Relevance 0
Regardless of the type of insults, liver fibrosis is characterized by the increased production of extracellular matrix (ECM) proteins.
Gene_expression (production) of ECM in extracellular matrix associated with fibrosis and cirrhosis
3) Confidence 0.08 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2981719 Disease Relevance 0.94 Pain Relevance 0.25
The potential contribution of ECM remodeling to
Gene_expression (contribution) of ECM
4) Confidence 0.08 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838960 Disease Relevance 0.27 Pain Relevance 0.55
to earlier work indicating that ECM molecules are
Gene_expression (molecules) of ECM
5) Confidence 0.08 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838960 Disease Relevance 0 Pain Relevance 0.52
The effects of acidosis/alkalosis on lung ECM protein synthesis are largely unknown.
Gene_expression (synthesis) of ECM in lung associated with alkalosis and acidosis
6) Confidence 0.07 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 1.47 Pain Relevance 0.09
Activated HSCs have been identified as the primary source of excess ECM components in liver fibrosis [4,18].
Gene_expression (source) of ECM in liver associated with fibrosis and cirrhosis
7) Confidence 0.06 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2981719 Disease Relevance 0.91 Pain Relevance 0.28
IL-1 causes both matrix degradation and downregulation of proteoglycan synthesis [37], but further studies are required to clarify whether FGF8 also downregulates ECM synthesis.
Gene_expression (synthesis) of ECM
8) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.10 Pain Relevance 0.53
In OA, synovitis is believed to be a reactive process as a result of cartilage destruction and the release of ECM-degradation products in the synovial fluid [1].
Gene_expression (products) of ECM-degradation in cartilage associated with synovitis and osteoarthritis
9) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.12 Pain Relevance 0.43
HSCs are a major source of ECM proteins in the liver.
Gene_expression (source) of ECM in ECM associated with cirrhosis
10) Confidence 0.04 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 1.27 Pain Relevance 0.48
Somewhat contrary to popular belief and several published reports, we found no evidence that elevated levels of exogenous glucosamine increased the transcription of genes with products associated with the synthesis of articular cartilage ECM components.
Gene_expression (synthesis) of ECM in articular cartilage
11) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0 Pain Relevance 0
Of relevance to OA, incubation with exogenous glucosamine alone led to about a twofold reduction in the expression of several genes associated with the synthesis of cartilage ECM, such as collagen type II, biglycan, and cartilage link protein, as well as a twofold increase in MMP-3 RNA (Table 4).
Gene_expression (synthesis) of ECM in cartilage associated with osteoarthritis
12) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.10 Pain Relevance 0.05
Of relevance to OA, incubation with exogenous glucosamine alone led to about a twofold reduction in the expression of several genes associated with the synthesis of cartilage ECM, such as collagen type II, biglycan, and cartilage link protein, as well as a twofold increase in MMP-3 RNA (Table 4).
Gene_expression (expression) of ECM in cartilage associated with osteoarthritis
13) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.10 Pain Relevance 0.05
Although glucosamine alone had no direct stimulatory effect on the expression of genes associated with ECM synthesis, as indicated in Tables 3, 4, 5 it proved to be a surprisingly potent, broad-spectrum inhibitor of IL-1 stimulation across the entire genome.
Gene_expression (synthesis) of ECM
14) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.23 Pain Relevance 0.29
CONCLUSIONS: Troglitazone prevented the progression of chronic pancreatitis via inhibition of ECM synthesis and proinflammatory cytokine production mediated by the inhibition of NF-kappaB activity.


Gene_expression (synthesis) of ECM
15) Confidence 0.01 Published 2005 Journal Rocz. Akad. Med. Bialymst. Section Body Doc Link 16358954 Disease Relevance 0 Pain Relevance 0

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