INT132191

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.96
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Cabin1) nucleus (Cabin1) cytoplasm (Cabin1)
Anatomy Link Frequency
muscles 1
Cabin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 2 100.00 Very High Very High Very High
fluoxetine 2 99.84 Very High Very High Very High
b2 receptor 2 99.80 Very High Very High Very High
antidepressant 2 99.62 Very High Very High Very High
Glutamate 3 98.92 Very High Very High Very High
bradykinin 8 97.44 Very High Very High Very High
tolerance 2 94.20 High High
Inflammatory response 4 90.32 High High
nociceptor 2 88.64 High High
antagonist 2 86.60 High High
Disease Link Frequency Relevance Heat
Injury 34 99.58 Very High Very High Very High
Stress 3 99.20 Very High Very High Very High
Shock 1 98.12 Very High Very High Very High
Death 51 97.92 Very High Very High Very High
Schizophrenia 6 96.28 Very High Very High Very High
Fatigue 2 92.00 High High
Muscular Atrophy 10 91.76 High High
Stress Incontinence 1 90.36 High High
INFLAMMATION 10 90.32 High High
Cancer 79 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of a calcineurin inhibitor, tacrolimus, on glutamate-dependent potentiation in pelvic-urethral reflex in anesthetized rats.
Regulation (Effects) of calcineurin associated with anesthesia and glutamate
1) Confidence 0.45 Published 2006 Journal Neuroscience Section Title Doc Link 16359812 Disease Relevance 0.09 Pain Relevance 0.35
Mood stabilizers such as lithium and valproic acid or the antidepressant fluoxetine had no effect on CaMKIV, CaMKKalpha, CaMKKbeta and calcineurin with the exception of an increase in CaMKKbeta following lithium treatment.
Neg (no) Regulation (effect) of calcineurin associated with antidepressant and fluoxetine
2) Confidence 0.09 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.10 Pain Relevance 0.24
In the current study, the effects of selected psychoactive drugs were investigated using Western blotting, in situ hybridization and immunocytochemistry to determine if they target CaM, calmodulin-dependent protein kinases (CaMK) or calcineurin.
Regulation (target) of calcineurin
3) Confidence 0.09 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.17 Pain Relevance 0
This increase was sensitive to calcineurin and B2 receptor inhibition.
Regulation (sensitive) of calcineurin associated with b2 receptor
4) Confidence 0.06 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17485565 Disease Relevance 0.14 Pain Relevance 0.54
Stress response to injury is evidenced by the regulation of calcineurin and RPS6K after IONT and C/EBP, JNK, and heat shock protein [52,53] genes after IONT and IONC.
Regulation (regulation) of calcineurin associated with stress, shock and injury
5) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.48 Pain Relevance 0.10
In muscles from healthy animals, transitions toward a slower MHC isoform profile have been attributed to a variety of factors that are sensitive to increased neuromuscular activity, such as the Ca2+-dependent phosphatase calcineurin [36] or peroxisome-proliferator-activated receptor-?
Regulation (sensitive) of calcineurin in muscles
6) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 0.98 Pain Relevance 0.05

General Comments

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