INT132223

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.75
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
spinal cord 4
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 30 99.04 Very High Very High Very High
Dopamine 69 97.64 Very High Very High Very High
Spinal cord 12 95.44 Very High Very High Very High
dopamine receptor 10 94.96 High High
central sensitization 3 94.96 High High
withdrawal 8 93.68 High High
Pain 5 86.96 High High
Calcitonin gene-related peptide 1 86.20 High High
Stimulus evoked pain 3 82.16 Quite High
Dorsal horn 3 81.20 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 38 100.00 Very High Very High Very High
Hypersensitivity 21 98.52 Very High Very High Very High
Neuroblastoma 2 97.16 Very High Very High Very High
Phototoxic Dermatitis 1 85.20 High High
Disease 49 82.24 Quite High
Disease Progression 1 81.44 Quite High
Pain 6 75.00 Quite High
Cognitive Disorder 9 73.76 Quite High
Nociception 1 64.28 Quite High
Hyperalgesia 1 61.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.
Negative_regulation (inhibitors) of Negative_regulation (inhibitors) of Akt in spinal cord associated with central sensitization, qutenza, hypersensitivity and spinal cord
1) Confidence 0.42 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.47 Pain Relevance 0.80
Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.
Negative_regulation (inhibitors) of Negative_regulation (inhibitors) of Akt in spinal cord associated with central sensitization, qutenza, hypersensitivity and spinal cord
2) Confidence 0.42 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.47 Pain Relevance 0.79
Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.
Negative_regulation (inhibitor) of Negative_regulation (inhibitors) of PKB associated with qutenza and hypersensitivity
3) Confidence 0.41 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.48 Pain Relevance 0.88
The PKB/Akt inhibitor, Akt inhibitor IV, has the same effect.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of Akt
4) Confidence 0.41 Published 2007 Journal Neuroscience Section Abstract Doc Link 17084039 Disease Relevance 0.33 Pain Relevance 0.80
Previously, using inhibitors of Akt or GSK3?
Negative_regulation (using) of Negative_regulation (inhibitors) of Akt
5) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0.09 Pain Relevance 0.38
g/mL) inhibited H2O2-induced cell apoptosis via inactivation of Akt, JNK and caspase 3 while high doses of EGb761 (250–500 ?
Negative_regulation (inhibited) of Negative_regulation (inactivation) of Akt associated with apoptosis
6) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 0.91 Pain Relevance 0

General Comments

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