INT132231

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.96
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Akt1 (Rattus norvegicus)
Pik3cg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 32 99.40 Very High Very High Very High
Spinal cord 16 91.68 High High
central sensitization 4 90.92 High High
Stimulus evoked pain 4 88.72 High High
withdrawal 4 76.60 Quite High
Dorsal horn 4 64.12 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 28 98.88 Very High Very High Very High
Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.
Negative_regulation (inhibitors) of Akt Binding (post-treatment) of PI3K associated with qutenza and hypersensitivity
1) Confidence 0.34 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.49 Pain Relevance 0.90
Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.
Negative_regulation (inhibitor) of Akt Binding (post-treatment) of PI3K associated with qutenza and hypersensitivity
2) Confidence 0.34 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.49 Pain Relevance 0.90
Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.
Negative_regulation (inhibitor) of Akt Binding (post-treatment) of PI3K associated with qutenza and hypersensitivity
3) Confidence 0.34 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.49 Pain Relevance 0.90
Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.
Negative_regulation (reduced) of Akt Binding (post-treatment) of PI3K associated with qutenza and hypersensitivity
4) Confidence 0.34 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.49 Pain Relevance 0.91

General Comments

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