INT132237

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.05
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
spinal cord 2
synaptic vesicles 2
spinal cord dorsal horn 2
Slc1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 62 99.68 Very High Very High Very High
Pain 56 99.64 Very High Very High Very High
Glutamate 173 99.52 Very High Very High Very High
Neuropathic pain 24 99.08 Very High Very High Very High
Dorsal horn 13 98.16 Very High Very High Very High
antinociception 5 97.48 Very High Very High Very High
Endep 8 94.64 High High
Morphine 7 94.28 High High
GABAergic 1 93.32 High High
gABA 5 92.80 High High
Disease Link Frequency Relevance Heat
Pain 64 99.64 Very High Very High Very High
Nervous System Injury 22 99.54 Very High Very High Very High
Neuropathic Pain 43 99.08 Very High Very High Very High
Nociception 27 90.92 High High
Bordatella Infection 2 75.00 Quite High
Hyperalgesia 14 73.44 Quite High
INFLAMMATION 22 50.00 Quite Low
Injury 2 28.48 Quite Low
Anxiety Disorder 1 18.88 Low Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCI induced a significant downregulation of EAAC1 expression primarily within the ipsilateral spinal cord dorsal horn when examined on postoperative day 7 using both Western blot and immunohistochemistry.
Negative_regulation (downregulation) of Gene_expression (expression) of EAAC1 in spinal cord dorsal horn associated with nervous system injury, dorsal horn and spinal cord
1) Confidence 0.56 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.62 Pain Relevance 0.50
In addition, concentrations of glutamate and aspartate were higher in baseline-P dialysates than in baseline-B dialysates, and the expression of the GTs (GLT-1, GLAST, and EAAC1) was downregulated by PTX treatment.
Negative_regulation (downregulated) of Gene_expression (expression) of EAAC1 associated with glutamate
2) Confidence 0.34 Published 2008 Journal Brain Res. Section Abstract Doc Link 18680732 Disease Relevance 0.13 Pain Relevance 1.32
Third, inhibition of reuptake through presynaptic EAAC1 and/or the glutamate/glutamine cycle in the spinal cord might result in a depletion of glutamate in synaptic vesicles and a decrease in presynaptically released glutamate, leading to a reduction in glutamate receptor-mediated nociceptive transmission.
Negative_regulation (inhibition) of Gene_expression (presynaptic) of EAAC1 in synaptic vesicles associated with nociception, glutamate, glutamate receptor and spinal cord
3) Confidence 0.21 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.25 Pain Relevance 1.36
Otherwise, the expression of other EAAT subtypes, GLAST and EAAC1, was also decreased in the spinal cord of neuropathic pain model animals [19,20,22-24].
Negative_regulation (decreased) of Gene_expression (expression) of EAAC1 in spinal cord associated with neuropathic pain and spinal cord
4) Confidence 0.18 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 1.04 Pain Relevance 1.28

General Comments

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