INT132240

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.62
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
neuronal 2
CSF 2
spinal cord dorsal horn 2
Slc1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 14 100.00 Very High Very High Very High
excitatory amino acid 6 100.00 Very High Very High Very High
Morphine 28 99.36 Very High Very High Very High
Antinociceptive 4 98.66 Very High Very High Very High
Spinal cord 4 98.64 Very High Very High Very High
Dorsal horn 4 98.16 Very High Very High Very High
Endep 22 97.66 Very High Very High Very High
intrathecal 8 96.14 Very High Very High Very High
Peripheral nerve injury 2 87.12 High High
antagonist 1 82.24 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 8 99.98 Very High Very High Very High
INFLAMMATION 1 30.40 Quite Low
Injury 1 28.48 Quite Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, amitriptyline/morphine co-infusion restores the antinociceptive effect of morphine and upregulates GLAST and GLT-1 expression and restores EAAC1 expression to baseline levels, thus reducing excitatory amino acid levels in the spinal CSF dialysates.
Positive_regulation (restores) of Gene_expression (expression) of EAAC1 in CSF associated with antinociceptive, endep, excitatory amino acid and morphine
1) Confidence 0.66 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.41
CCI induced a significant downregulation of EAAC1 expression primarily within the ipsilateral spinal cord dorsal horn when examined on postoperative day 7 using both Western blot and immunohistochemistry.
Positive_regulation (induced) of Gene_expression (expression) of EAAC1 in spinal cord dorsal horn associated with nervous system injury, dorsal horn and spinal cord
2) Confidence 0.45 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.62 Pain Relevance 0.50
We previously showed that intrathecal co-administration of amitriptyline with morphine upregulates the expression of the glial glutamate transporters glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) and restores neuronal glutamate transporter excitatory amino acid carrier 1 (EAAC1) expression in chronically morphine-infused rats.
Positive_regulation (restores) of Gene_expression (expression) of EAAC1 in neuronal associated with glutamate, endep, excitatory amino acid, morphine and intrathecal
3) Confidence 0.44 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.04

General Comments

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