INT132243

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.86
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grik4) nucleus (Grik4)
Anatomy Link Frequency
DRG 2
neurons 1
anterior pituitary 1
Grik4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 10 100.00 Very High Very High Very High
Glutamate receptor 3 100.00 Very High Very High Very High
GABAergic 14 99.20 Very High Very High Very High
Central grey 12 97.80 Very High Very High Very High
Glutamate 14 97.66 Very High Very High Very High
Pain 2 92.84 High High
Neurotransmitter 8 91.16 High High
Spinal cord 2 88.04 High High
agonist 24 85.56 High High
substance P 18 82.08 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 11 100.00 Very High Very High Very High
Urological Neuroanatomy 12 97.80 Very High Very High Very High
Pain 2 92.84 High High
Nociception 4 80.56 Quite High
Adenoma 5 39.24 Quite Low
Attention Deficit Hyperactivity Disorder 1 15.44 Low Low
Sprains And Strains 1 10.76 Low Low
Stress 48 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also show that the high-affinity kainate receptor subunits KA1 and KA2 are expressed in central terminals of DRG neurons and are co-expressed with low-affinity receptor subunits in the same terminals.
Gene_expression (co-expressed) of KA1 in DRG associated with dorsal root ganglion
1) Confidence 0.58 Published 2006 Journal Pain Section Abstract Doc Link 16360275 Disease Relevance 0.54 Pain Relevance 0.51
We also show that the high-affinity kainate receptor subunits KA1 and KA2 are expressed in central terminals of DRG neurons and are co-expressed with low-affinity receptor subunits in the same terminals.
Gene_expression (expressed) of KA1 in DRG associated with dorsal root ganglion
2) Confidence 0.58 Published 2006 Journal Pain Section Abstract Doc Link 16360275 Disease Relevance 0.53 Pain Relevance 0.51
Glutamate or certain aspartate analogues have been found to stimulate PRL, GH and LH release and rat anterior pituitary cells express mRNA of glutamate receptors GluR1, GluR2, GluR3, GluR4, GluR5, GluR6, GluR7, KA1 and KA2 subunits (765).
Gene_expression (express) of KA1 in anterior pituitary associated with glutamate and glutamate receptor
3) Confidence 0.11 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.64
These results suggest that presynaptic kainate receptors have a low permeability to Ca(2+), and that their activation elicits a presynaptic depolarization large enough to activate presynaptic VDCCs.
Gene_expression (presynaptic) of kainate
4) Confidence 0.04 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20303934 Disease Relevance 0.24 Pain Relevance 0.64
Presynaptic kainate receptors increase GABAergic neurotransmission in rat periaqueductal gray neurons.
Gene_expression (Presynaptic) of kainate in neurons associated with gabaergic and central grey
5) Confidence 0.04 Published 2010 Journal Eur. J. Pharmacol. Section Title Doc Link 20303934 Disease Relevance 0.55 Pain Relevance 0.68

General Comments

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