INT132246

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2006
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 22.00
Pain Relevance 7.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a8) extracellular region (S100a8) plasma membrane (S100a8)
cytoskeleton (S100a8) cytoplasm (S100a8)
Anatomy Link Frequency
neutrophil 3
brain 2
leukocytes 2
plasma 1
spinal cord 1
S100a8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 615 100.00 Very High Very High Very High
cytokine 247 100.00 Very High Very High Very High
Pain 20 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
Spinal cord 74 99.28 Very High Very High Very High
Inflammatory mediators 34 99.04 Very High Very High Very High
Arthritis 15 98.88 Very High Very High Very High
chemokine 48 98.08 Very High Very High Very High
Analgesic 6 97.60 Very High Very High Very High
Inflammatory response 75 94.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 709 100.00 Very High Very High Very High
Pain 9 100.00 Very High Very High Very High
Repression 1 100.00 Very High Very High Very High
Atherosclerosis 7 99.76 Very High Very High Very High
Arthritis 19 98.88 Very High Very High Very High
Bacterial Respiratory Disease 11 98.76 Very High Very High Very High
Targeted Disruption 247 98.60 Very High Very High Very High
Disease Progression 31 98.44 Very High Very High Very High
Infection 179 98.28 Very High Very High Very High
Disease 276 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RT-QPCR analysis confirmed that neutrophil depletion in the mice significantly decreased, but did not completely abrogate the upregulation of the aforementioned genes (including S100A8, S100A9, IL-1?
Negative_regulation (decreased) of S100A8 in neutrophil
1) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.50 Pain Relevance 0.12
The RT-QPCR analysis confirmed that neutrophil depletion in the mice significantly decreased, but did not completely abrogate the upregulation of the aforementioned genes (including S100A8, S100A9, IL-1?
Neg (not) Negative_regulation (abrogate) of S100A8 in neutrophil
2) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.50 Pain Relevance 0.12
In conclusion, S100A8/A9 deficiency did not influence the host response after infection with two doses of uropathogenic E.
Negative_regulation (deficiency) of S100A8 associated with infection
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.61 Pain Relevance 0.18
Thus, targeted deletion of S100A9 leads to a complete lack of a functional S100A8/A9 complex in the mouse [12], [13].
Negative_regulation (lack) of S100A8
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.02 Pain Relevance 0.18
To determine whether S100A8/A9 deficiency affected production of inflammatory mediators, KC, MIP-2 and TNF-?
Spec (whether) Negative_regulation (deficiency) of S100A8 associated with chemokine and inflammatory mediators
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.83 Pain Relevance 0.37
Blocking S100A8/A9 inhibits neutrophil migration in response to LPS [42].
Negative_regulation (Blocking) of S100A8 in neutrophil
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 0.72 Pain Relevance 0.03
S100A8 is almost not detectable at the protein level in mature phagocytes of S100A9 KO mice despite normal S100A8 mRNA levels, probably due to the elevated metabolism of S100A8 in the absence of its binding partner.
Negative_regulation (metabolism) of S100A8 in phagocytes associated with targeted disruption
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 0.96 Pain Relevance 0.19
The first possibility seems unlikely because expression levels of S100A8/A9 and IL-1F8 were similar in cultured keratinocytes from mice of both genotypes.
Negative_regulation (levels) of S100A8 in keratinocytes
8) Confidence 0.34 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.59 Pain Relevance 0.25
The reduced but not the oxidized S100A8 homodimer is strongly chemotactic for leukocytes [121].
Neg (not) Negative_regulation (reduced) of S100A8 homodimer in leukocytes
9) Confidence 0.22 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.64 Pain Relevance 0.07
In addition, mice lacking MRP8/MRP14 complexes are protected from endotoxin-induced lethal shock and E. coli-induced abdominal sepsis [140, 143] and exhibit reduced lesion volume, brain swelling, and inflammatory cell infiltration during cerebral ischemia [142].
Negative_regulation (lacking) of MRP8 in brain associated with inflammation, cv general 4 under development, ischemia, shock, cerebral edema and sepsis
10) Confidence 0.13 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.64 Pain Relevance 0.40
These include a decrease in glial activity (astrocytes and microglial cells) as well as pain mediators such as dynorphin, COX-2 and chemotactic cytokine receptor (CCR2).
Negative_regulation (decrease) of chemotactic cytokine receptor in microglial cells associated with pain, dynorphin and cytokine
11) Confidence 0.13 Published 2006 Journal Pain Section Abstract Doc Link 16360279 Disease Relevance 1.08 Pain Relevance 0.95
Significantly, elevated levels of colonic RNA for pro-inflammatory cytokines interleukin (IL)-6 and IL-12 were also decreased toward normal with NTX.
Negative_regulation (decreased) of pro-inflammatory associated with inflammation and cytokine
12) Confidence 0.12 Published 2008 Journal J Immunotoxicol Section Abstract Doc Link 18569389 Disease Relevance 1.73 Pain Relevance 0.78
Together these data show that many endogenous TLR activators exhibit pro-inflammatory properties in vivo.

4.3.

Negative_regulation (exhibit) of pro-inflammatory associated with inflammation
13) Confidence 0.12 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.10 Pain Relevance 0.34
However, BSO pretreatment did not have any impact on proinflammatory cytokine level (Supplementary Data) but drastically reduced the anti-inflammatory cytokine level (Figure 6(e)) compared with eAE, thus eliminating the healing effect of eAE.

3.7.

Neg (not) Negative_regulation (reduced) of anti-inflammatory cytokine associated with inflammation and cytokine
14) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2976071 Disease Relevance 0.67 Pain Relevance 0.54
These include a decrease in glial activity (astrocytes and microglial cells) as well as pain mediators such as dynorphin, COX-2 and chemotactic cytokine receptor (CCR2).
Negative_regulation (decrease) of chemotactic cytokine receptor in astrocytes associated with pain, dynorphin and cytokine
15) Confidence 0.05 Published 2006 Journal Pain Section Abstract Doc Link 16360279 Disease Relevance 1.08 Pain Relevance 0.95
The most beneficial effect on decreasing pro-inflammatory cytokines in the brain and spinal cord was found in this group of mice.
Negative_regulation (decreasing) of pro-inflammatory in brain associated with inflammation, spinal cord and cytokine
16) Confidence 0.02 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2429976 Disease Relevance 0.77 Pain Relevance 0.27
The mode of action of this mixture seems to be owing to both a reduction of pro-inflammatory factors and a stimulation of at least one potentially anti-inflammatory factor, PGD2.
Negative_regulation (reduction) of pro-inflammatory associated with inflammation
17) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 1.15 Pain Relevance 0.37
Some examples in centenarians are as follows: reduction of pro-inflammatory, pro-atherosclerotic properties of platelets [119], increased resistance to inhibitory actions of homocysteine on nitric oxide generation [119], low plasma membrane lipid peroxide levels, high membrane fluidity with normal content of sialic acid [120-123] and increased plasma cortisol, one of the most potent anti-inflammatory molecules [124,106].
Negative_regulation (reduction) of pro-inflammatory in plasma associated with inflammation and atherosclerosis
18) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 1.60 Pain Relevance 0.26
The most beneficial effect on decreasing pro-inflammatory cytokines in the brain and spinal cord was found in this group of mice.
Negative_regulation (decreasing) of pro-inflammatory in spinal cord associated with inflammation, spinal cord and cytokine
19) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2429976 Disease Relevance 0.77 Pain Relevance 0.27
These inhibitors also suppress the activity of many pro-inflammatory and immune cells (Lipworth 2005).
Negative_regulation (suppress) of pro-inflammatory in immune cells associated with inflammation
20) Confidence 0.00 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 0.77 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox