INT132315

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.40
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (DLL1) extracellular region (DLL1) plasma membrane (DLL1)
cell-cell signaling (DLL1)
Anatomy Link Frequency
spinal cord 2
PC-3 2
ducts 1
DLL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 4 99.64 Very High Very High Very High
Spinal cord 4 98.12 Very High Very High Very High
Neuropathic pain 7 96.88 Very High Very High Very High
Neuropeptide 1 96.48 Very High Very High Very High
Chronic pancreatitis 8 95.76 Very High Very High Very High
allodynia 1 95.12 Very High Very High Very High
Peripheral nerve injury 2 89.40 High High
tetrodotoxin 2 84.72 Quite High
Gabapentin 1 82.08 Quite High
pregabalin 2 80.88 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 99.16 Very High Very High Very High
Calcification 34 99.14 Very High Very High Very High
Neuropathic Pain 8 96.88 Very High Very High Very High
Pancreatitis 8 95.76 Very High Very High Very High
Nervous System Injury 2 89.40 High High
Reprotox - General 1 8 80.00 Quite High
Pain 1 78.24 Quite High
Cancer 1 74.92 Quite High
Metaplasia 1 73.28 Quite High
INFLAMMATION 3 69.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of the Ca2+ channel alpha2/delta1 subunit, gamma-aminobutyric acid A receptor alpha5 subunit, Na+ channels and nicotinic acetylcholine receptors in the DRG and dorsal spinal cord indicates their potential roles in neuropathic pain control.
Positive_regulation (Upregulation) of delta1 in spinal cord associated with dorsal root ganglion, neuropathic pain and spinal cord
1) Confidence 0.67 Published 2005 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 16370375 Disease Relevance 0.78 Pain Relevance 0.74
In contrast, the Notch ligand Delta-like1 (Dll1) levels were higher in LNCaP compared with PC-3 and PC-3M cells.
Positive_regulation (higher) of Delta-like1 in PC-3
2) Confidence 0.45 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.31 Pain Relevance 0.12
Up-regulation of the voltage-gated Ca(2+) channel subunit alpha(2)delta-1 in DRG (dorsal root ganglion) neurons and the spinal cord correlates with the onset of neuropathic pain symptoms such as allodynia in several animal models of neuropathic pain.
Positive_regulation (Up-regulation) of delta-1 in spinal cord associated with ganglion cysts, dorsal root ganglion, allodynia, neuropathic pain and spinal cord
3) Confidence 0.45 Published 2010 Journal Biochem. Soc. Trans. Section Abstract Doc Link 20298215 Disease Relevance 0.48 Pain Relevance 0.83
In contrast, the Notch ligand Delta-like1 (Dll1) levels were higher in LNCaP compared with PC-3 and PC-3M cells.
Positive_regulation (higher) of Dll1 in PC-3
4) Confidence 0.43 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.31 Pain Relevance 0.12
In Table 4 the results of a logistic regression of three categorized delta Agatston score as dependent variable are reported: no delta coronary calcification (reference category), those with a medium increment (delta <1000) and those with severe (delta >1000) coronary calcification increment.
Positive_regulation (increment) of delta associated with calcification
5) Confidence 0.08 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.39 Pain Relevance 0
The transcripts of Delta-like1 and Jagged1 were increased 3.7-fold and 1.3-fold, respectively, while those of HERP1 were elevated 2.4-fold in the ectatic ducts of CP, compared to normal ducts.
Positive_regulation (increased) of Delta-like1 in ducts associated with chronic pancreatitis
6) Confidence 0.03 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18069660 Disease Relevance 1.13 Pain Relevance 0.63

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox