INT132318

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.49
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl, GH1) extracellular region (Ghrl, GH1) cytoplasm (Ghrl)
Anatomy Link Frequency
nerve 4
pituitary 2
body 2
Ghrl (Rattus norvegicus)
GH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Eae 9 98.44 Very High Very High Very High
COX-2 inhibitor 4 87.68 High High
tolerance 14 84.64 Quite High
Inflammation 44 82.88 Quite High
agonist 59 81.64 Quite High
Central nervous system 1 68.32 Quite High
cINOD 2 65.60 Quite High
qutenza 1 52.00 Quite High
cytokine 40 50.80 Quite High
antagonist 59 45.40 Quite Low
Disease Link Frequency Relevance Heat
Repression 18 99.92 Very High Very High Very High
Body Weight 30 99.66 Very High Very High Very High
Targeted Disruption 51 96.76 Very High Very High Very High
Fetal Weight 3 91.04 High High
Diabetes Mellitus 15 90.40 High High
Appetite Loss 213 89.12 High High
Cancer 150 88.76 High High
Hypoglycemia 12 86.72 High High
Sepsis 15 85.12 High High
Impaired Glucose Tolerance 15 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in addition to stimulating GH secretion, ghrelin possesses several other endocrine and extraendocrine biological activities that are explained by the widespread distribution of ghrelin and GHS-R1a expression.
ghrelin Positive_regulation (stimulating) of Localization (secretion) of GH
1) Confidence 0.32 Published 2005 Journal J. Endocrinol. Invest. Section Abstract Doc Link 16370568 Disease Relevance 0.12 Pain Relevance 0.09
Ghrelin is expressed abundantly by the placenta [604], and ghrelin can stimulate GH release by human fetal pituitary cells in vitro [605].
ghrelin Positive_regulation (stimulate) of Localization (release) of GH in pituitary
2) Confidence 0.06 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.76 Pain Relevance 0.11
Not only does ghrelin stimulate GH secretion (via the GH secretagogue-1a (GHS-1a) receptor) but it also promotes food intake (via the orexigenic NPY system) and decreases sympathetic nerve activity.
ghrelin Positive_regulation (stimulate) of Localization (secretion) of GH in nerve
3) Confidence 0.06 Published 2010 Journal Indian Journal of Palliative Care Section Body Doc Link PMC3012235 Disease Relevance 1.18 Pain Relevance 0.21
Not only does ghrelin stimulate GH secretion (via the GH secretagogue-1a (GHS-1a) receptor) but it also promotes food intake (via the orexigenic NPY system) and decreases sympathetic nerve activity.
ghrelin Positive_regulation (stimulate) of Localization (secretion) of GH in nerve
4) Confidence 0.04 Published 2010 Journal Indian Journal of Palliative Care Section Body Doc Link PMC3012235 Disease Relevance 1.19 Pain Relevance 0.21
In mice, transgenic overexpression of desacyl-ghrelin decreases food intake, gastric emptying, GH (female animal) and IGF-I (both sexes) concentrations, body weight and length, and GH release induced by exogenous ghrelin [75].
ghrelin Positive_regulation (induced) of Localization (release) of GH in body associated with targeted disruption and body weight
5) Confidence 0.04 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.39 Pain Relevance 0.04
Thus, GHS-R1a is a physiological mediator of ghrelin's stimulation of GH secretion, repression of oxygen consumption and locomotor activity, and enhancement of appetite.
ghrelin Positive_regulation (stimulation) of Localization (secretion) of GH associated with eae and repression
6) Confidence 0.04 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.86 Pain Relevance 0.19

General Comments

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