INT132324

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.90
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SYK) cytosol (SYK) plasma membrane (SYK)
cytoplasm (SYK)
SYK (Homo sapiens)
Pain Link Frequency Relevance Heat
Antihistamine 1 98.96 Very High Very High Very High
antagonist 3 97.12 Very High Very High Very High
spastic colon 2 91.24 High High
chemokine 10 90.00 High High
Pain 2 89.68 High High
nud 1 89.32 High High
Neuropeptide 1 62.08 Quite High
corticosteroid 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
T-cell Lymphoma 42 93.88 High High
Cancer 82 92.52 High High
Functional Bowel Disorder 2 91.24 High High
Pain 1 89.68 High High
Dyspepsia 1 89.32 High High
Eosinophilia 4 87.84 High High
Gastrointestinal Disease 2 75.00 Quite High
Rhinitis 2 66.88 Quite High
Lymphatic System Cancer 244 66.56 Quite High
Apoptosis 10 64.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Novel drugs with an increased potential in the control of MC function (e.g., anti-IgE antibodies, the intracellular protein tyrosine kinase inhibitor Syk) and mediator release (e.g., second generation antihistamines, proteinase-activated receptor antagonists) may be useful pharmacological tools for these common disorders.
Localization (release) of Syk associated with antagonist and antihistamine
1) Confidence 0.78 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16371078 Disease Relevance 0.48 Pain Relevance 0.51
FISH showed no SYK/ITK translocation in 86 cases.
Localization (translocation) of SYK
2) Confidence 0.25 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.66 Pain Relevance 0.04
The recent finding of SYK/ITK translocations in rare PTCLs led us to examine the expression of Syk PTK in 141 PTCLs.
Localization (translocations) of SYK
3) Confidence 0.22 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.76 Pain Relevance 0.04

General Comments

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