INT132333

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.87
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNA1) transmembrane transport (KCNA1)
Anatomy Link Frequency
plasma 1
brains 1
thumb 1
KCNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endep 18 99.74 Very High Very High Very High
Hippocampus 7 99.60 Very High Very High Very High
potassium channel 85 98.80 Very High Very High Very High
hyperexcitability 5 96.12 Very High Very High Very High
Neuropathic pain 5 94.88 High High
Neuronal excitability 3 87.28 High High
Spinal cord 12 56.80 Quite High
lidocaine 2 50.00 Quite Low
antagonist 3 46.32 Quite Low
anesthesia 2 33.12 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 44 99.34 Very High Very High Very High
Chronic Lymphoid Leukemia 76 97.52 Very High Very High Very High
Neuropathic Pain 5 94.88 High High
Epilepsy 19 94.16 High High
Anxiety Disorder 3 93.60 High High
Tinnitus 1 75.40 Quite High
Apoptosis 22 70.40 Quite High
Cancer 26 63.52 Quite High
Stress 7 63.04 Quite High
Toxicity 3 60.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Lidocaine reversibly inhibited Kv 3.1 and Kv 1.1 channels in a concentration-dependent manner.
Negative_regulation (inhibited) of Kv 1.1
1) Confidence 0.47 Published 2006 Journal Otol. Neurotol. Section Body Doc Link 16371858 Disease Relevance 0.08 Pain Relevance 0
In sharp contrast, the present data show a substantial reduction of the hand area projected on the surface of the ipsilesional hemisphere, amounting to 52%, 77% and 43% in Mk1, Mk2 and Mk3, respectively (Fig. 3), not far from the area reductions observed in the contralesional hemisphere (see [31]), amounting to 67%, 89% and 100% in Mk1, Mk2 and Mk3, respectively.
Negative_regulation (reduction) of Mk1
2) Confidence 0.21 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1224856 Disease Relevance 0.06 Pain Relevance 0
The manual dexterity of each hand was assessed in Mk1, Mk2 and Mk3 using our modified "Brinkman board" task, as described in detail earlier [25,31,52], testing the ability to grasp a food pellet using the opposition of the thumb and the index finger (precision grip).
Negative_regulation (assessed) of Mk1 in thumb
3) Confidence 0.21 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1224856 Disease Relevance 0 Pain Relevance 0.03
To explore further the relationships between the two main antibody targets, the potassium channels and the clinical syndromes, we first examined the relative distribution of Lgi1, Caspr2 and Kv1.1 in the hippocampus and cerebellum of mouse brains.
Spec (examined) Negative_regulation (distribution) of Kv1 in brains associated with syndrome, hippocampus and potassium channel
4) Confidence 0.09 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.10 Pain Relevance 0.23
CONCLUSIONS: Since amitriptyline inhibited Kv1.1 and Kv7.2/7.3 channels only at toxicologically relevant plasma concentrations, our results suggest a role for these channels in the neuroexcitatory side effects of amitriptyline.
Negative_regulation (inhibited) of Kv1.1 in plasma
5) Confidence 0.08 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17456683 Disease Relevance 0 Pain Relevance 0
Amitriptyline is a potent blocker of human Kv1.1 and Kv7.2/7.3 channels.
Negative_regulation (blocker) of Kv1.1 associated with endep
6) Confidence 0.08 Published 2007 Journal Anesth. Analg. Section Title Doc Link 17456683 Disease Relevance 0.28 Pain Relevance 0.45
RESULTS: Amitriptyline inhibited Kv1.1 and Kv7.2/7.3 channels in a concentration-dependent and reversible manner.
Negative_regulation (inhibited) of Kv1.1
7) Confidence 0.08 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17456683 Disease Relevance 0 Pain Relevance 0
Experiments with real-time PCR demonstrated that treatment with EA caused a dose-dependent decline in the expression of three Wnt target genes, LEF-1, cyclin D1 and fibronectin, which reflects EA inhibition of Wnt/?
Negative_regulation (inhibition) of EA
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.35 Pain Relevance 0

General Comments

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