INT132334

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.52
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNA1) transmembrane transport (KCNA1)
Anatomy Link Frequency
oocytes 2
auditory system 2
KCNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
electroacupuncture 91 100.00 Very High Very High Very High
Hyperalgesia 14 99.76 Very High Very High Very High
potassium channel 97 99.24 Very High Very High Very High
antagonist 4 93.28 High High
withdrawal 2 86.84 High High
Inflammation 24 86.04 High High
lidocaine 2 50.00 Quite Low
Pain 7 29.08 Quite Low
Acupuncture 13 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 18 100.00 Very High Very High Very High
Hyperalgesia 16 99.76 Very High Very High Very High
Syndrome 45 87.36 High High
Limbic Encephalitis 27 86.52 High High
INFLAMMATION 27 86.04 High High
Isaacs Syndrome 25 65.96 Quite High
Neuromyelitis Optica 1 63.88 Quite High
Myasthenia Gravis 1 59.84 Quite High
Endometriosis (extended) 3 57.84 Quite High
Thymoma 7 56.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fig. 3Missense mutation T226K induces loss of function of human Kv1.1 channels expressed in Xenopus oocytes. a–c Representative family of whole-oocyte currents recorded from oocytes expressing human Kv1.1-WT (a), Kv1.1-T226K (b), and both Kv1.1 WT and T226K (c).
Negative_regulation (loss) of Gene_expression (expressed) of Kv1 in oocytes
1) Confidence 0.43 Published 2006 Journal Neurogenetics Section Body Doc Link PMC1820748 Disease Relevance 0 Pain Relevance 0
The small effect at clinically relevant concentrations suggests that the physiologic roles of Kv 3.1 and Kv 1.1 channels in auditory neurons seem not to be impaired during the therapeutic or diagnostic application of lidocaine in the auditory system.


Negative_regulation (impaired) of Gene_expression (roles) of Kv 1.1 in auditory system
2) Confidence 0.35 Published 2006 Journal Otol. Neurotol. Section Body Doc Link 16371858 Disease Relevance 0 Pain Relevance 0
As expected, there was a marked reduction in Kv1 currents with the specific VGKC blocker ?
Negative_regulation (reduction) of Gene_expression (currents) of Kv1 associated with potassium channel
3) Confidence 0.08 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.88 Pain Relevance 0.28
Adrenalectomy blocked EA-produced anti-edema, but not EA anti-hyperalgesia.
Negative_regulation (blocked) of Gene_expression (produced) of EA associated with pressure and volume under development, hyperalgesia and electroacupuncture
4) Confidence 0.00 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1976320 Disease Relevance 0.64 Pain Relevance 0.87

General Comments

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