INT132335

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 36
Total Number 40
Disease Relevance 18.31
Pain Relevance 13.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNA1) transmembrane transport (KCNA1)
Anatomy Link Frequency
oocytes 6
SH-SY5Y 2
cerebellum 2
plasma 1
quadriceps 1
KCNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 1193 100.00 Very High Very High Very High
electroacupuncture 992 100.00 Very High Very High Very High
Analgesic 65 99.98 Very High Very High Very High
Hyperalgesia 84 99.76 Very High Very High Very High
Hippocampus 101 99.38 Very High Very High Very High
Pain 334 98.72 Very High Very High Very High
Pyramidal cell 26 97.84 Very High Very High Very High
Action potential 9 96.76 Very High Very High Very High
midbrain 15 94.32 High High
Substantia nigra 10 93.52 High High
Disease Link Frequency Relevance Heat
Isaacs Syndrome 325 100.00 Very High Very High Very High
Pressure And Volume Under Development 108 100.00 Very High Very High Very High
Hyperalgesia 96 99.76 Very High Very High Very High
Targeted Disruption 44 99.28 Very High Very High Very High
Pain 362 98.72 Very High Very High Very High
Cancer 249 98.52 Very High Very High Very High
Syndrome 582 98.08 Very High Very High Very High
Nociception 9 97.72 Very High Very High Very High
Urological Neuroanatomy 210 97.68 Very High Very High Very High
Stress 44 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested whether the missense mutation alters human Kv1.1 channel function by expressing Kv1.1-T226K in Xenopus oocytes.
Gene_expression (expressing) of Kv1 in oocytes
1) Confidence 0.77 Published 2006 Journal Neurogenetics Section Body Doc Link PMC1820748 Disease Relevance 0.06 Pain Relevance 0
The Kv1.1 potassium channel subunit is expressed during development in neuronal and glial cells in the central and peripheral nervous systems [14].
Gene_expression (expressed) of Kv1 in neuronal associated with potassium channel
2) Confidence 0.77 Published 2006 Journal Neurogenetics Section Body Doc Link PMC1820748 Disease Relevance 1.24 Pain Relevance 0.31
We then mimicked the heterozygous situation by co-injecting equal amounts of Kv1.1 WT and T226K mutant cRNAs.
Gene_expression (amounts) of Kv1
3) Confidence 0.67 Published 2006 Journal Neurogenetics Section Body Doc Link PMC1820748 Disease Relevance 0 Pain Relevance 0
Mutations in two neuronal ion-channel genes KCNA1 and CACNA1A abundantly expressed in the cerebellum account for the majority of the identified cases of episodic ataxia.
Gene_expression (expressed) of KCNA1 in cerebellum associated with ataxia
4) Confidence 0.65 Published 2009 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 19645908 Disease Relevance 1.40 Pain Relevance 0.18
METHODS: Patch-clamp recordings were performed on the pharmacologic action of lidocaine on Kv 3.1 channels natively expressed in SH-SY5Y cells and Kv 1.1 channels expressed in HEK 293 cells.
Gene_expression (expressed) of Kv 1.1 in SH-SY5Y
5) Confidence 0.63 Published 2006 Journal Otol. Neurotol. Section Body Doc Link 16371858 Disease Relevance 0.08 Pain Relevance 0
Fig. 3Missense mutation T226K induces loss of function of human Kv1.1 channels expressed in Xenopus oocytes. a–c Representative family of whole-oocyte currents recorded from oocytes expressing human Kv1.1-WT (a), Kv1.1-T226K (b), and both Kv1.1 WT and T226K (c).
Gene_expression (expressed) of Kv1 in oocytes
6) Confidence 0.60 Published 2006 Journal Neurogenetics Section Body Doc Link PMC1820748 Disease Relevance 0 Pain Relevance 0
Fig. 3Missense mutation T226K induces loss of function of human Kv1.1 channels expressed in Xenopus oocytes. a–c Representative family of whole-oocyte currents recorded from oocytes expressing human Kv1.1-WT (a), Kv1.1-T226K (b), and both Kv1.1 WT and T226K (c).
Gene_expression (expressing) of Kv1 in oocytes
7) Confidence 0.60 Published 2006 Journal Neurogenetics Section Body Doc Link PMC1820748 Disease Relevance 0.11 Pain Relevance 0
Fig. 3Missense mutation T226K induces loss of function of human Kv1.1 channels expressed in Xenopus oocytes. a–c Representative family of whole-oocyte currents recorded from oocytes expressing human Kv1.1-WT (a), Kv1.1-T226K (b), and both Kv1.1 WT and T226K (c).
Gene_expression (expressing) of Kv1 in oocytes
8) Confidence 0.60 Published 2006 Journal Neurogenetics Section Body Doc Link PMC1820748 Disease Relevance 0.11 Pain Relevance 0
Fig. 3Missense mutation T226K induces loss of function of human Kv1.1 channels expressed in Xenopus oocytes. a–c Representative family of whole-oocyte currents recorded from oocytes expressing human Kv1.1-WT (a), Kv1.1-T226K (b), and both Kv1.1 WT and T226K (c).
Gene_expression (expressing) of Kv1 in oocytes
9) Confidence 0.60 Published 2006 Journal Neurogenetics Section Body Doc Link PMC1820748 Disease Relevance 0.17 Pain Relevance 0
Co-expression of WT and mutant cRNAs significantly reduced whole-oocyte current compared to expression of WT Kv1.1 alone.



Gene_expression (expression) of Kv1 in oocyte
10) Confidence 0.60 Published 2006 Journal Neurogenetics Section Abstract Doc Link PMC1820748 Disease Relevance 0.74 Pain Relevance 0.12
The small effect at clinically relevant concentrations suggests that the physiologic roles of Kv 3.1 and Kv 1.1 channels in auditory neurons seem not to be impaired during the therapeutic or diagnostic application of lidocaine in the auditory system.


Gene_expression (roles) of Kv 1.1 in auditory system
11) Confidence 0.54 Published 2006 Journal Otol. Neurotol. Section Body Doc Link 16371858 Disease Relevance 0 Pain Relevance 0
METHODS: Patch-clamp recordings were performed on the pharmacologic action of lidocaine on Kv 3.1 channels natively expressed in SH-SY5Y cells and Kv 1.1 channels expressed in HEK 293 cells.
Gene_expression (expressed) of Kv 1.1 in SH-SY5Y
12) Confidence 0.54 Published 2006 Journal Otol. Neurotol. Section Body Doc Link 16371858 Disease Relevance 0.08 Pain Relevance 0
The Kv1.1 potassium channel subunit is expressed during development in neuronal and glial cells in the central and peripheral nervous systems [14].
Gene_expression (expressed) of Kv1 in glial cells associated with potassium channel
13) Confidence 0.26 Published 2006 Journal Neurogenetics Section Body Doc Link PMC1820748 Disease Relevance 1.24 Pain Relevance 0.31
In the cerebellum, Caspr2 (C and D) is expressed in the molecular (mol) and granule cell layers (GCL), but not in the pinceau (green arrows) where Kv1.1 (C) as well as Lgi1 (D) are strongly expressed.
Gene_expression (expressed) of Kv1 in cerebellum
14) Confidence 0.16 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.08 Pain Relevance 0.22
Caspr2-knockout mice show dispersed, non-clustered Kv1 neural expression (Poliak et al., 2003), similar to that seen in one study of patients with Caspr2-mutations (Strauss et al., 2006).
Gene_expression (expression) of Kv1 in neural associated with targeted disruption
15) Confidence 0.14 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.57 Pain Relevance 0.11
In the CA3 area of the hippocampus, Caspr2 (A and B) is strongly expressed in the stratum radiatum (rad), whereas Kv1.1 (A) and Lgi1 (B) are most prominent in the mossy fibre layer (mf) where Caspr2 is almost absent.
Gene_expression (expressed) of Kv1 in hippocampus associated with hippocampus
16) Confidence 0.14 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.12 Pain Relevance 0.24
Immunoprecipitation of VGKCs by the patients’ antibodies was sensitive to low concentrations (e.g. 0.025%) of sodium dodecyl sulphate, which do not usually affect the binding of antibodies directly to their targets (e.g. antibodies to acetylcholine receptors or MuSK in myasthenia, unpublished results), whereas the commercial antibodies to Kv1.1 or 1.2, as expected, were able to immunoprecipitate the 125I-?
Gene_expression (expected) of Kv1
17) Confidence 0.14 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0 Pain Relevance 0.03
Earlier studies suggested that the Kv1s were the target antigens in neuromyotonia (Arimura et al., 1997; Hart et al., 1997), but most of those sera had lower VGKC-antibody titres compared with those studied here.
Gene_expression (titres) of Kv1s associated with isaacs syndrome and potassium channel
18) Confidence 0.14 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.33 Pain Relevance 0.28
Of the other three, one had Lgi1-antibodies, one had Kv1.2 antibodies and one had no other VGKC-complex antibody detected.


Gene_expression (antibodies) of Kv1 associated with potassium channel
19) Confidence 0.14 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.08 Pain Relevance 0.25
Although commercial Kv1.1 antibodies, for instance, bound to the Kv1.1-transfected cells, none of the patients’ IgG showed detectable binding (e.g.
Gene_expression (antibodies) of Kv1
20) Confidence 0.14 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.18 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox