INT132377

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.75
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
band 2
peritoneal macrophages 2
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 95.04 Very High Very High Very High
Inflammation 75 92.40 High High
cINOD 2 88.32 High High
Central nervous system 10 74.96 Quite High
Substantia nigra 27 53.44 Quite High
cytokine 27 41.36 Quite Low
COX2 1 25.00 Low Low
Dopamine 29 15.12 Low Low
midbrain 4 7.20 Low Low
Thalamus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 84 94.64 High High
Periodontitis 30 85.40 High High
Infection 63 79.00 Quite High
African Trypanosomiasis 26 53.44 Quite High
Adhesions 6 50.60 Quite High
Parkinson's Disease 19 50.00 Quite Low
Disease 54 48.72 Quite Low
Bites And Stings 2 8.20 Low Low
Body Weight 16 5.00 Very Low Very Low Very Low
Periodontal Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In peritoneal macrophages, iNOS activity decreased from D10 (?
Negative_regulation (decreased) of iNOS Binding (activity) of in peritoneal macrophages
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2821905 Disease Relevance 0.25 Pain Relevance 0
The competition between arginase and iNOS for their common substrate, L-arginine, reduces NO production and favors polyamine synthesis, required for trypanosome development [7].
Neg (NO) Negative_regulation (reduces) of iNOS Binding (competition) of
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.12 Pain Relevance 0.04
Hypericum treatment abolished the staining for iNOS and nitrotyrosine (Figure 6c and 6e respectively).
Negative_regulation (abolished) of iNOS Binding (staining) of
3) Confidence 0.29 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.28 Pain Relevance 0.03
Background values from an equivalent area near each lane were subtracted from each band to calculate mean band density and iNOS or DARPP-32 immunoreactivity was normalized by density of ?
Negative_regulation (normalized) of iNOS Binding (immunoreactivity) of in band
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2674956 Disease Relevance 0 Pain Relevance 0.03
Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2.
Negative_regulation (disrupting) of iNOS Binding (binding) of
5) Confidence 0.16 Published 2005 Journal Science Section Abstract Doc Link 16373578 Disease Relevance 0.09 Pain Relevance 0.18

General Comments

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