INT132392

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.37
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

UOX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 72.96 Quite High
Arthritis 9 71.92 Quite High
adenocard 5 53.84 Quite High
cINOD 1 33.28 Quite Low
corticosteroid 1 31.12 Quite Low
fibrosis 1 29.00 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperuricemia 42 99.76 Very High Very High Very High
Aging 3 95.52 Very High Very High Very High
Disease 4 94.52 High High
Asymptomatic Diseases 1 85.20 High High
Cardiovascular Disease 1 80.16 Quite High
Hypertension 2 78.00 Quite High
Crystal Associated Disease 57 75.00 Quite High
Arthritis 9 72.96 Quite High
Tumor Lysis Syndrome 31 50.00 Quite Low
Hypersensitivity 25 46.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Humans lack the enzyme uricase, which catalyzes the conversion of uric acid to allantoin.
Negative_regulation (lack) of uricase
1) Confidence 0.43 Published 2005 Journal Curr. Pharm. Des. Section Abstract Doc Link 16375732 Disease Relevance 1.00 Pain Relevance 0.10
Mice with gene inactivation of urate oxidase have hyperuricemia and renal tubulopathy. 9
Negative_regulation (inactivation) of urate oxidase associated with hyperuricemia
2) Confidence 0.29 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.37 Pain Relevance 0.03
Because IgG antibody was not detected until pUox was declining or undetectable, it might have evolved earlier but have been sequestered in complexes with circulating antigen that were rapidly cleared, or circulating antigen might have prevented antibody from binding to immobilized PEG-uricase in the ELISA.
Negative_regulation (declining) of pUox
3) Confidence 0.28 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526556 Disease Relevance 0 Pain Relevance 0

General Comments

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