INT132392

Context Info Confidence 0.43 First Reported 2005 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.37 Pain Relevance 0.13

UOX (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 9 72.96 Arthritis 9 71.92 adenocard 5 53.84 cINOD 1 33.28 corticosteroid 1 31.12 fibrosis 1 29.00 Pain 3 5.00 Bioavailability 2 5.00 headache 2 5.00 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Hyperuricemia 42 99.76 Aging 3 95.52 Disease 4 94.52 Asymptomatic Diseases 1 85.20 Cardiovascular Disease 1 80.16 Hypertension 2 78.00 Crystal Associated Disease 57 75.00 Arthritis 9 72.96 Tumor Lysis Syndrome 31 50.00 Hypersensitivity 25 46.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Humans lack the enzyme uricase, which catalyzes the conversion of uric acid to allantoin.

Negative_regulation (lack) of uricase

1) Confidence 0.43 Published 2005 Journal Curr. Pharm. Des. Section Abstract Doc Link 16375732 Disease Relevance 1.00 Pain Relevance 0.10

Mice with gene inactivation of urate oxidase have hyperuricemia and renal tubulopathy. 9

Negative_regulation (inactivation) of urate oxidase associated with hyperuricemia

2) Confidence 0.29 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.37 Pain Relevance 0.03

Because IgG antibody was not detected until pUox was declining or undetectable, it might have evolved earlier but have been sequestered in complexes with circulating antigen that were rapidly cleared, or circulating antigen might have prevented antibody from binding to immobilized PEG-uricase in the ELISA.

Negative_regulation (declining) of pUox

3) Confidence 0.28 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526556 Disease Relevance 0 Pain Relevance 0

General Comments

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