INT13240

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Context Info
Confidence 0.76
First Reported 1991
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 94
Total Number 96
Disease Relevance 57.81
Pain Relevance 10.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TF) extracellular region (TF) cytoplasmic membrane-bounded vesicle (TF)
transmembrane transport (TF)
Anatomy Link Frequency
monocytes 7
blood 6
plasma 5
smooth muscle cells 4
myocardium 2
TF (Homo sapiens)
Pain Link Frequency Relevance Heat
tail-flick 3 100.00 Very High Very High Very High
dexamethasone 1 100.00 Very High Very High Very High
Inflammation 423 99.92 Very High Very High Very High
cytokine 148 99.82 Very High Very High Very High
medulla 10 99.28 Very High Very High Very High
aspirin 34 98.76 Very High Very High Very High
Angina 117 98.72 Very High Very High Very High
Inflammatory response 27 95.62 Very High Very High Very High
Morphine 4 95.60 Very High Very High Very High
rheumatoid arthritis 188 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 210 100.00 Very High Very High Very High
Burns 70 100.00 Very High Very High Very High
Atherosclerotic Plaque 32 100.00 Very High Very High Very High
Nociception 2 100.00 Very High Very High Very High
INFLAMMATION 454 99.92 Very High Very High Very High
Anaemia 375 99.80 Very High Very High Very High
Coagulation Disorder 34 99.80 Very High Very High Very High
Thrombophilia 30 99.74 Very High Very High Very High
Disorder Of Lipid Metabolism 5 99.68 Very High Very High Very High
Restless Legs Syndrome 126 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitory anti-TF antibodies prolonged the clotting time of LPS-stimulated blood, indicating that the shortened clotting time was due to induction of TF expression.
Gene_expression (expression) of TF in blood associated with coagulation disorder
1) Confidence 0.76 Published 2000 Journal Thromb. Haemost. Section Abstract Doc Link 10744152 Disease Relevance 1.04 Pain Relevance 0.18
Since cardiomyocytes constitutively express TF and release TF positive procoagulant MP under inflammatory conditions, it is reasonable to speculate that MPs bearing TF in ongoing AMI may arise from necrotic myocardium [24,25].
Gene_expression (express) of TF in myocardium associated with inflammation and myocardial infarction
2) Confidence 0.76 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.81 Pain Relevance 0.09
TF expression by circulating monocytes is associated with thrombotic and inflammatory complications in a variety of diseases.
Gene_expression (expression) of TF in monocytes associated with inflammation and disease
3) Confidence 0.76 Published 1995 Journal Blood Section Abstract Doc Link 7492771 Disease Relevance 0.27 Pain Relevance 0.08
In ten chronic uremic patients on regular hemodialysis treatment in vitro experiments revealed that stimulation of opioid receptors with morphine did not significantly change the mitogen-induced proliferative response of peripheral blood lymphocytes and interleukin-2 (IL-2) receptor expression on PHA-stimulated lymphocytes, while it appreciably decreased surface transferrin (Trf) receptor expression on PHA-stimulated lymphocytes.
Gene_expression (expression) of Trf in lymphocytes associated with opioid receptor, uremia and morphine
4) Confidence 0.75 Published 1991 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1664419 Disease Relevance 0.26 Pain Relevance 0.46
METHODS AND RESULTS: Histamine (10(-8) to 10(-5) mol/L) induced TF expression in a concentration-dependent manner in human aortic endothelial and vascular smooth muscle cells, whereas TF pathway inhibitor expression remained unaffected.
Gene_expression (expression) of TF in smooth muscle cells
5) Confidence 0.69 Published 2005 Journal Circulation Section Body Doc Link 16009787 Disease Relevance 0 Pain Relevance 0
METHODS AND RESULTS: Histamine (10(-8) to 10(-5) mol/L) induced TF expression in a concentration-dependent manner in human aortic endothelial and vascular smooth muscle cells, whereas TF pathway inhibitor expression remained unaffected.
Gene_expression (expression) of TF in smooth muscle cells
6) Confidence 0.69 Published 2005 Journal Circulation Section Body Doc Link 16009787 Disease Relevance 0 Pain Relevance 0
Hence, this study investigates whether histamine induces tissue factor (TF) expression in vascular cells.
Gene_expression (expression) of TF
7) Confidence 0.69 Published 2005 Journal Circulation Section Abstract Doc Link 16009787 Disease Relevance 0.45 Pain Relevance 0.09
Inhibitory anti-TF antibodies prolonged the clotting time of LPS-stimulated blood, indicating that the shortened clotting time was due to induction of TF expression.
Gene_expression (prolonged) of anti-TF in blood associated with coagulation disorder
8) Confidence 0.66 Published 2000 Journal Thromb. Haemost. Section Abstract Doc Link 10744152 Disease Relevance 1.06 Pain Relevance 0.17
Although we found a significant correlation between TF antigen and TF activity (data not shown), the indicative role of TF activity showed differences among subpopulations.
Gene_expression (antigen) of TF
9) Confidence 0.66 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.52 Pain Relevance 0
Although we found a significant correlation between TF antigen and TF activity (data not shown), the indicative role of TF activity showed differences among subpopulations.
Gene_expression (antigen) of TF
10) Confidence 0.66 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.52 Pain Relevance 0
However TF antigen levels may not adequately reflect the thrombogenic potential of circulating TF, [20,21].
Gene_expression (levels) of TF
11) Confidence 0.66 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.60 Pain Relevance 0
Treatment with rhGH has been shown to reduce protein catabolism,13,14 increase muscle area and strength,14–18 increase erythropoietin synthesis,19 and to improve inflammation status and quality of life.20 A recent 6-month study showed a positive effect of GH treatment on lean body mass and cardiovascular risk factors.21 Furthermore, GH administration is associated with improvements in several nutritional parameters, such as increases in serum insulin-like growth factor-I (IGF-I),13,14,22 serum albumin14 and transferrin,13 and a reduction in blood urea nitrogen.13
Gene_expression (serum) of transferrin in blood associated with inflammation
12) Confidence 0.65 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.53 Pain Relevance 0.05
g/ml transferrin, 5 ng/ml sodium selenite, 2.5 u g/ml human recombinant epidermal growth factor (EGF), 8.4 ng/ml cholera toxin, 0.5% dimethyl sulfoxide (DMSO), 0.5 ?
Gene_expression (/) of transferrin associated with vibrio infection
13) Confidence 0.65 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.23 Pain Relevance 0
In a subset of experiments, GC were cultured in a defined serum-free medium of HEPES-buffered DMEM:F10 (1:1) containing insulin (300 mU/ml), hydrocortisone (40 ng/ml), transferrin (5 ?
Gene_expression (containing) of transferrin
14) Confidence 0.65 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC155641 Disease Relevance 0 Pain Relevance 0
The isoelectric focussing pattern of serum sialotransferrin was typical of CDG type I in Patients 1, 2 and 3 and was shifted towards the less sialylated bands in case 4.
Gene_expression (typical) of transferrin in bands
15) Confidence 0.65 Published 2001 Journal Eur. J. Paediatr. Neurol. Section Abstract Doc Link 11589167 Disease Relevance 1.96 Pain Relevance 0.18
Viruses were grown in MDCK cells in DMEM/F12 with ITS+ (containing insulin, human transferrin, and selenous acid; BD Biosciences, Franklin Lakes, NJ) and trypsin (0.5 ?
Gene_expression (containing) of transferrin in MDCK
16) Confidence 0.65 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2994788 Disease Relevance 0.45 Pain Relevance 0
Expression of TF on the cell surface and its appearance as a soluble molecule are characteristic features of acute and chronic inflammation in conditions such as sepsis and atherosclerosis.
Gene_expression (Expression) of TF associated with inflammation, increased venous pressure under development and sepsis
17) Confidence 0.65 Published 2006 Journal Thromb. Res. Section Abstract Doc Link 16378835 Disease Relevance 1.24 Pain Relevance 0.23
TF expression is mediated by nuclear factor kappaB and amplified by activated platelets.
Gene_expression (expression) of TF in platelets
18) Confidence 0.61 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10521382 Disease Relevance 0.10 Pain Relevance 0.21
Hence, we hypothesized that aspirin, which inhibits LPS-induced, nuclear factor kappaB-dependent TF expression in vitro and platelet activation in vivo, may suppress LPS-induced coagulation in humans.
Gene_expression (expression) of TF in platelet associated with aspirin
19) Confidence 0.61 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10521382 Disease Relevance 0.09 Pain Relevance 0.41
During Gram-negative septic shock, lipopolysaccharide (LPS, endotoxin) induces tissue factor (TF) expression.
Gene_expression (expression) of TF associated with sepsis
20) Confidence 0.61 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10521382 Disease Relevance 0.10 Pain Relevance 0.21

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