INT132419

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.22
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ANXA5) intracellular (ANXA5) cytoplasm (ANXA5)
ANXA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 150 99.36 Very High Very High Very High
rheumatoid arthritis 14 95.08 Very High Very High Very High
ischemia 25 94.04 High High
opioid receptor 10 92.16 High High
nMDA receptor 12 90.08 High High
Opioid 6 88.72 High High
narcan 4 88.00 High High
agonist 5 85.92 High High
opiate 4 84.48 Quite High
Enkephalin 2 84.28 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 171 99.80 Very High Very High Very High
Atherosclerosis 104 99.48 Very High Very High Very High
Pressure And Volume Under Development 24 96.16 Very High Very High Very High
Death 36 95.84 Very High Very High Very High
Rheumatoid Arthritis 18 95.08 Very High Very High Very High
Rupture 14 95.08 Very High Very High Very High
Cv Unclassified Under Development 23 94.04 High High
Hypoxia 13 93.68 High High
Myocardial Infarction 74 92.72 High High
Necrosis 23 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative RT-PCR confirmed that DAMGO increased mRNA levels of Annexin V, an apoptosis-induced gene.
Positive_regulation (increased) of Annexin V associated with apoptosis
1) Confidence 0.59 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16377088 Disease Relevance 0.10 Pain Relevance 0.78
Other proteins, like ANXV, ANXVI, IGIP/PA28, and HABP-1, were increased at 24 hours and remained highly elevated at 96 hours – and indication that heparin has more extended effects on selected proteins.


Positive_regulation (increased) of ANXV
2) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.26 Pain Relevance 0.04
We found that in this experiment, the degree of redistribution of PS depended on the concentration of IAA/CCCP: higher concentration of IAA/CCCP is associated with increased annexin-V and PI uptake during the reperfusion (Fig. 1).
Positive_regulation (increased) of annexin-V
3) Confidence 0.19 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808556 Disease Relevance 0.50 Pain Relevance 0.19
Level of circulating annexin V and anti-annexin V and anti-cardiolipin IgG antibodies were determined by enzyme linked immunosorbent assay (ELISA) using high-sensitivity commercial kits (Aeskulisa, REF: 7204, Germany for aCLAs, Bender Medsystems company, Cat.
Positive_regulation (circulating) of annexin V
4) Confidence 0.18 Published 2009 Journal Thromb J Section Body Doc Link PMC2724414 Disease Relevance 0.43 Pain Relevance 0
Annexin V, RGS4 and CREB genes showed pronounced increase in expression after stimulation with DAMGO.
Positive_regulation (increase) of Annexin V
5) Confidence 0.18 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16377088 Disease Relevance 0.09 Pain Relevance 0.78
In this experiment, the portion of the HTB-15 and CRL-1690 cells showing both annexin-V and PI negativity after trypsinization ranged from 85 to 95%.
Positive_regulation (showing) of annexin-V
6) Confidence 0.15 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808556 Disease Relevance 0.57 Pain Relevance 0.06
Level of circulating annexin V and anti-annexin V and anti-cardiolipin IgG antibodies were determined by enzyme linked immunosorbent assay (ELISA) using high-sensitivity commercial kits (Aeskulisa, REF: 7204, Germany for aCLAs, Bender Medsystems company, Cat.
Positive_regulation (circulating) of anti-annexin V
7) Confidence 0.15 Published 2009 Journal Thromb J Section Body Doc Link PMC2724414 Disease Relevance 0.43 Pain Relevance 0
Ketamine 0.1 mM itself was found not to induce apoptosis by the observation that annexin-V affinity or PI uptake was not increased.
Neg (not) Positive_regulation (increased) of annexin-V associated with ketamine and apoptosis
8) Confidence 0.14 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808556 Disease Relevance 1.35 Pain Relevance 0.45
A recent study in a rabbit model showed higher 99mTc-annexin V accumulation in grade IV atheroma than in other more stable lesions. 99mTc-annexin V may be useful in identifying atheroma at risk for rupture and also possibly in assessing response to anti-atherosclerotic therapy [156].


Positive_regulation (accumulation) of 99mTc-annexin V associated with rupture and atherosclerosis
9) Confidence 0.10 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 1.49 Pain Relevance 0.10

General Comments

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